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GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress.
Zhou W, Zhao Z, Lin A, Yang JZ, Xu J, Wilder-Romans K, Yang A, Li J, Solanki S, Speth JM, Walker N, Scott AJ, Wang L, Wen B, Andren A, Zhang L, Kothari AU, Yao Y, Peterson ER, Korimerla N, Werner CK, Ullrich A, Liang J, Jacobson J, Palavalasa S, O'Brien AM, Elaimy AL, Ferris SP, Zhao SG, Sarkaria JN, Győrffy B, Zhang S, Al-Holou WN, Umemura Y, Morgan MA, Lawrence TS, Lyssiotis CA, Peters-Golden M, Shah YM, Wahl DR. Zhou W, et al. Among authors: lyssiotis ca. Cancer Discov. 2024 Jan 12;14(1):158-175. doi: 10.1158/2159-8290.CD-23-0437. Cancer Discov. 2024. PMID: 37902550
Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis.
Wahl DR, Dresser J, Wilder-Romans K, Parsels JD, Zhao SG, Davis M, Zhao L, Kachman M, Wernisch S, Burant CF, Morgan MA, Feng FY, Speers C, Lyssiotis CA, Lawrence TS. Wahl DR, et al. Among authors: lyssiotis ca. Cancer Res. 2017 Feb 15;77(4):960-970. doi: 10.1158/0008-5472.CAN-16-2008. Epub 2016 Dec 6. Cancer Res. 2017. PMID: 27923831 Free PMC article.
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy.
Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, Mashadova O, Nicolay BN, Tolstyka ZP, Halbrook CJ, Chandrasekaran S, Asara JM, Crawford HC, Cantley LC, Kimmelman AC, Wahl DR, Lyssiotis CA. Nelson BS, et al. Among authors: lyssiotis ca. Cancer Metab. 2020 Jan 2;8:1. doi: 10.1186/s40170-019-0202-2. eCollection 2020. Cancer Metab. 2020. PMID: 31908776 Free PMC article.
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma.
Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR. Zhou W, et al. Among authors: lyssiotis ca. Nat Commun. 2020 Jul 30;11(1):3811. doi: 10.1038/s41467-020-17512-x. Nat Commun. 2020. PMID: 32732914 Free PMC article.
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.
Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, Lyssiotis CA, Bian Z, Shotwell JB, Yadav VN, Koschmann C, Chinnaiyan AM, Blüml S, Judkins AR, Venneti S. Chung C, et al. Among authors: lyssiotis ca. Cancer Cell. 2020 Sep 14;38(3):334-349.e9. doi: 10.1016/j.ccell.2020.07.008. Epub 2020 Aug 13. Cancer Cell. 2020. PMID: 32795401 Free PMC article.
Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma.
Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, Sulman EP, Lorenzi PL, Tan L, Shan M, Tolstyka ZP, Kachman M, Zhang L, Gao S, Deem AK, Genovese G, Scaglioni PP, Lyssiotis CA, Viale A, Draetta GF. Puca F, et al. Among authors: lyssiotis ca. Cancer Discov. 2021 Nov;11(11):2904-2923. doi: 10.1158/2159-8290.CD-20-1437. Epub 2021 May 26. Cancer Discov. 2021. PMID: 34039636 Free PMC article.
196 results