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Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Griebel G, Pichat P, Beeské S, Leroy T, Redon N, Jacquet A, Françon D, Bert L, Even L, Lopez-Grancha M, Tolstykh T, Sun F, Yu Q, Brittain S, Arlt H, He T, Zhang B, Wiederschain D, Bertrand T, Houtmann J, Rak A, Vallée F, Michot N, Augé F, Menet V, Bergis OE, George P, Avenet P, Mikol V, Didier M, Escoubet J. Griebel G, et al. Among authors: lopez grancha m. Sci Rep. 2015 Jan 6;5:7642. doi: 10.1038/srep07642. Sci Rep. 2015. PMID: 25560837 Free PMC article.
The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents.
Griebel G, Stemmelin J, Lopez-Grancha M, Boulay D, Boquet G, Slowinski F, Pichat P, Beeské S, Tanaka S, Mori A, Fujimura M, Eguchi J. Griebel G, et al. Among authors: lopez grancha m. Sci Rep. 2019 Dec 2;9(1):18045. doi: 10.1038/s41598-019-54557-5. Sci Rep. 2019. PMID: 31792284 Free PMC article.
SAR110894, a potent histamine H₃-receptor antagonist, displays procognitive effects in rodents.
Griebel G, Pichat P, Pruniaux MP, Beeské S, Lopez-Grancha M, Genet E, Terranova JP, Castro A, Sánchez JA, Black M, Varty GB, Weiner I, Arad M, Barak S, De Levie A, Guillot E. Griebel G, et al. Among authors: lopez grancha m. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14. doi: 10.1016/j.pbb.2012.04.004. Epub 2012 Apr 21. Pharmacol Biochem Behav. 2012. PMID: 22542742
Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.
Do TM, Capdevila C, Pradier L, Blanchard V, Lopez-Grancha M, Schussler N, Steinmetz A, Beninga J, Boulay D, Dugay P, Verdier P, Aubin N, Dargazanli G, Chaves C, Genet E, Lossouarn Y, Loux C, Michoux F, Moindrot N, Chanut F, Gury T, Eyquem S, Valente D, Bergis O, Rao E, Lesuisse D. Do TM, et al. Among authors: lopez grancha m. Mol Ther Methods Clin Dev. 2020 Aug 21;19:58-77. doi: 10.1016/j.omtm.2020.08.014. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33005703 Free PMC article.
SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy.
Delay-Goyet P, Blanchard V, Schussler N, Lopez-Grancha M, Ménager J, Mary V, Sultan E, Buzy A, Guillemot JC, Stemmelin J, Bertrand P, Rooney T, Pradier L, Barnéoud P. Delay-Goyet P, et al. Among authors: lopez grancha m. Alzheimers Dement (N Y). 2016 Nov 3;2(4):267-280. doi: 10.1016/j.trci.2016.10.002. eCollection 2016 Nov. Alzheimers Dement (N Y). 2016. PMID: 29067314 Free PMC article.
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.
Latta-Mahieu M, Elmer B, Bretteville A, Wang Y, Lopez-Grancha M, Goniot P, Moindrot N, Ferrari P, Blanc V, Schussler N, Brault E, Roudières V, Blanchard V, Yang ZY, Barneoud P, Bertrand P, Roucourt B, Carmans S, Bottelbergs A, Mertens L, Wintmolders C, Larsen P, Hersley C, McGathey T, Racke MM, Liu L, Lu J, O'Neill MJ, Riddell DR, Ebneth A, Nabel GJ, Pradier L. Latta-Mahieu M, et al. Among authors: lopez grancha m. Glia. 2018 Mar;66(3):492-504. doi: 10.1002/glia.23260. Epub 2017 Nov 14. Glia. 2018. PMID: 29134678
17 results