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Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Shapiro JS, et al. Among authors: lopaschuk g. Nat Cell Biol. 2023 Oct;25(10):1478-1494. doi: 10.1038/s41556-023-01225-6. Epub 2023 Sep 25. Nat Cell Biol. 2023. PMID: 37749225
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis.
Gopal K, Abdualkader AM, Li X, Greenwell AA, Karwi QG, Altamimi TR, Saed C, Uddin GM, Darwesh AM, Jamieson KL, Kim R, Eaton F, Seubert JM, Lopaschuk GD, Ussher JR, Al Batran R. Gopal K, et al. Among authors: lopaschuk gd. J Biol Chem. 2023 Dec;299(12):105375. doi: 10.1016/j.jbc.2023.105375. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865313 Free PMC article.
Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy.
Greenwell AA, Tabatabaei Dakhili SA, Wagg CS, Saed CT, Chan JSF, Yang K, Mangra-Bala IA, Stenlund MJ, Eaton F, Gopal K, Dyck JRB, Lopaschuk GD, Ussher JR. Greenwell AA, et al. Among authors: lopaschuk gd. J Am Heart Assoc. 2024 Apr 2;13(7):e032697. doi: 10.1161/JAHA.123.032697. Epub 2024 Mar 27. J Am Heart Assoc. 2024. PMID: 38533954 Free article. No abstract available.
Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.
Sun Q, Güven B, Wagg CS, Almeida de Oliveira A, Silver H, Zhang L, Chen B, Wei K, Ketema EB, Karwi QG, Persad KL, Vu J, Wang F, Dyck JRB, Oudit GY, Lopaschuk GD. Sun Q, et al. Among authors: lopaschuk gd. Cardiovasc Res. 2024 Mar 30;120(4):360-371. doi: 10.1093/cvr/cvae006. Cardiovasc Res. 2024. PMID: 38193548
441 results