Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy

Amanda A Greenwell; Seyed Amirhossein Tabatabaei Dakhili; Cory S Wagg; Christina T Saed; Jordan S F Chan; Kunyan Yang; Indiresh A Mangra-Bala; Magnus J Stenlund; Farah Eaton; Keshav Gopal; Jason R B Dyck; Gary D Lopaschuk; John R Ussher

doi:10.1161/JAHA.123.032697

Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy

J Am Heart Assoc. 2024 Apr 2;13(7):e032697. doi: 10.1161/JAHA.123.032697. Epub 2024 Mar 27.

Authors

Amanda A Greenwell^{1

2

3}, Seyed Amirhossein Tabatabaei Dakhili^{1

2

3}, Cory S Wagg^{2

3

4}, Christina T Saed^{1

2

3}, Jordan S F Chan^{1

2

3}, Kunyan Yang^{1

2

3}, Indiresh A Mangra-Bala^{1

2

3}, Magnus J Stenlund^{1

2

3}, Farah Eaton^{1

2

3}, Keshav Gopal^{1

2

3}, Jason R B Dyck^{2

3

4}, Gary D Lopaschuk^{2

3

4}, John R Ussher^{1

2

3}

Affiliations

¹ Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton AB Canada.
² Cardiovascular Research Institute University of Alberta Edmonton AB Canada.
³ Alberta Diabetes Institute University of Alberta Edmonton AB Canada.
⁴ Department of Pediatrics University of Alberta Edmonton AB Canada.

PMID: 38533954
DOI: 10.1161/JAHA.123.032697

No abstract available

Keywords: diabetic cardiomyopathy; diastolic function; ketone metabolism; succinyl CoA:3‐ketoacid CoA transferase; type 2 diabetes.

MeSH terms

Coenzyme A-Transferases
Diabetes Mellitus*
Diabetic Cardiomyopathies* / drug therapy
Humans
Ketone Bodies

Substances

Coenzyme A-Transferases
Ketone Bodies