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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Tong H, Huang J, Xiao Q, He B, Dong X, Liu Y, Yang X, Han D, Wang Z, Wang X, Ying W, Zhang R, Wei Y, Xu C, Zhou Y, Li Y, Cai M, Wang Q, Xue M, Li G, Fang K, Zhang H, Yang H. Tong H, et al. Among authors: liu y. Nat Biotechnol. 2023 Jan;41(1):108-119. doi: 10.1038/s41587-022-01419-7. Epub 2022 Aug 11. Nat Biotechnol. 2023. PMID: 35953673
Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e.
Wang X, Zhang R, Yang D, Li G, Fan Z, Du H, Wang Z, Liu Y, Lin J, Wu X, Shi L, Yang H, Zhou Y. Wang X, et al. Among authors: liu y. Adv Sci (Weinh). 2023 Jun;10(17):e2206813. doi: 10.1002/advs.202206813. Epub 2023 Apr 25. Adv Sci (Weinh). 2023. PMID: 37098587 Free PMC article.
In vivo treatment of tyrosinaemia with hypercompact Cas12f1.
Guo R, Li Z, Li G, Zhang H, Zhang C, Huo X, Zhang X, Yang X, Yang R, Liu Y, Sun X, Liu X, Yang H, Zhou Y, Xu C. Guo R, et al. Among authors: liu y, liu x. Cell Discov. 2023 Jul 18;9(1):73. doi: 10.1038/s41421-023-00554-y. Cell Discov. 2023. PMID: 37460535 Free PMC article. No abstract available.
RNA base editing therapy cures hearing loss induced by OTOF gene mutation.
Xue Y, Tao Y, Wang X, Wang X, Shu Y, Liu Y, Kang W, Chen S, Cheng Z, Yan B, Xie Y, Bi L, Jia H, Li J, Xiao Q, Chen L, Yao X, Shi L, Yang H, Wu H. Xue Y, et al. Among authors: liu y. Mol Ther. 2023 Dec 6;31(12):3520-3530. doi: 10.1016/j.ymthe.2023.10.019. Epub 2023 Nov 2. Mol Ther. 2023. PMID: 37915172
191,053 results
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