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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Root AR, Cao W, Li B, LaPan P, Meade C, Sanford J, Jin M, O'Sullivan C, Cummins E, Lambert M, Sheehan AD, Ma W, Gatto S, Kerns K, Lam K, D'Antona AM, Zhu L, Brady WA, Benard S, King A, He T, Racie L, Arai M, Barrett D, Stochaj W, LaVallie ER, Apgar JR, Svenson K, Mosyak L, Yang Y, Chichili GR, Liu L, Li H, Burke S, Johnson S, Alderson R, Finlay WJJ, Lin L, Olland S, Somers W, Bonvini E, Gerber HP, May C, Moore PA, Tchistiakova L, Bloom L. Root AR, et al. Among authors: lin l. Antibodies (Basel). 2016 Mar 4;5(1):6. doi: 10.3390/antib5010006. Antibodies (Basel). 2016. PMID: 31557987 Free PMC article.
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, Fitz L, Greco R, Somers WS, Mosyak L. Xu ZB, et al. Among authors: lin l. J Biol Chem. 2004 Nov 26;279(48):50401-9. doi: 10.1074/jbc.M409216200. Epub 2004 Sep 13. J Biol Chem. 2004. PMID: 15364937 Free article.
A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Bridges KG, Chopra R, Lin L, Svenson K, Tam A, Jin G, Cowling R, Lovering F, Akopian TN, DiBlasio-Smith E, Annis-Freeman B, Marvell TH, LaVallie ER, Zollner RS, Bard J, Somers WS, Stahl ML, Kriz RW. Bridges KG, et al. Among authors: lin l. Peptides. 2006 Jul;27(7):1877-85. doi: 10.1016/j.peptides.2006.02.003. Epub 2006 Mar 30. Peptides. 2006. PMID: 16574278
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W. Mosyak L, et al. Among authors: lin l. Protein Sci. 2008 Jan;17(1):16-21. doi: 10.1110/ps.073287008. Epub 2007 Nov 27. Protein Sci. 2008. PMID: 18042673 Free PMC article.
Pyroglutamate and O-linked glycan determine functional production of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions.
Zhong X, Kieras E, Sousa E, D'Antona A, Baber JC, He T, Desharnais J, Wood L, Luxenberg D, Stahl M, Kriz R, Lin L, Somers W, Fitz LJ, Wright JF. Zhong X, et al. Among authors: lin l. J Biol Chem. 2013 Jan 11;288(2):1409-19. doi: 10.1074/jbc.M112.417717. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184956 Free PMC article.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O. Fennell BJ, et al. Among authors: lin l. MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21. MAbs. 2013. PMID: 23995618 Free PMC article.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
Tu C, Terraube V, Tam AS, Stochaj W, Fennell BJ, Lin L, Stahl M, LaVallie ER, Somers W, Finlay WJ, Mosyak L, Bard J, Cunningham O. Tu C, et al. Among authors: lin l. J Biol Chem. 2016 Jan 15;291(3):1267-76. doi: 10.1074/jbc.M115.688010. Epub 2015 Oct 29. J Biol Chem. 2016. PMID: 26515064 Free PMC article.
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