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Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.
Holmes B, Lee J, Landon KA, Benavides-Serrato A, Bashir T, Jung ME, Lichtenstein A, Gera J. Holmes B, et al. Among authors: lichtenstein a. J Biol Chem. 2016 Jul 1;291(27):14146-14159. doi: 10.1074/jbc.M116.726927. Epub 2016 May 11. J Biol Chem. 2016. PMID: 27226604 Free PMC article.
Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.
Shi Y, Daniels-Wells TR, Frost P, Lee J, Finn RS, Bardeleben C, Penichet ML, Jung ME, Gera J, Lichtenstein A. Shi Y, et al. Among authors: lichtenstein a. Cancer Res. 2016 Oct 1;76(19):5822-5831. doi: 10.1158/0008-5472.CAN-16-1019. Epub 2016 Aug 16. Cancer Res. 2016. PMID: 27530328 Free PMC article.
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.
Hoang B, Frost P, Shi Y, Belanger E, Benavides A, Pezeshkpour G, Cappia S, Guglielmelli T, Gera J, Lichtenstein A. Hoang B, et al. Among authors: lichtenstein a. Blood. 2010 Nov 25;116(22):4560-8. doi: 10.1182/blood-2010-05-285726. Epub 2010 Aug 4. Blood. 2010. PMID: 20686120 Free PMC article.
Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity.
Martin J, Masri J, Cloninger C, Holmes B, Artinian N, Funk A, Ruegg T, Anderson L, Bashir T, Bernath A, Lichtenstein A, Gera J. Martin J, et al. Among authors: lichtenstein a. J Biol Chem. 2011 May 6;286(18):16402-13. doi: 10.1074/jbc.M110.205096. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454539 Free PMC article.
836 results