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A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance.
Heithoff DM, Mahan SP, Barnes V L, Leyn SA, George CX, Zlamal JE, Limwongyut J, Bazan GC, Fried JC, Fitzgibbons LN, House JK, Samuel CE, Osterman AL, Low DA, Mahan MJ. Heithoff DM, et al. Among authors: leyn sa. EBioMedicine. 2023 Mar;89:104461. doi: 10.1016/j.ebiom.2023.104461. Epub 2023 Feb 15. EBioMedicine. 2023. PMID: 36801104 Free PMC article.
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV. Osterman IA, et al. Among authors: leyn sa. Nat Chem Biol. 2020 Oct;16(10):1071-1077. doi: 10.1038/s41589-020-0578-x. Epub 2020 Jun 29. Nat Chem Biol. 2020. PMID: 32601485
Novel inositol catabolic pathway in Thermotoga maritima.
Rodionova IA, Leyn SA, Burkart MD, Boucher N, Noll KM, Osterman AL, Rodionov DA. Rodionova IA, et al. Among authors: leyn sa. Environ Microbiol. 2013 Aug;15(8):2254-66. doi: 10.1111/1462-2920.12096. Epub 2013 Feb 27. Environ Microbiol. 2013. PMID: 23441918
B-Vitamin Sharing Promotes Stability of Gut Microbial Communities.
Sharma V, Rodionov DA, Leyn SA, Tran D, Iablokov SN, Ding H, Peterson DA, Osterman AL, Peterson SN. Sharma V, et al. Among authors: leyn sa. Front Microbiol. 2019 Jul 2;10:1485. doi: 10.3389/fmicb.2019.01485. eCollection 2019. Front Microbiol. 2019. PMID: 31333610 Free PMC article.
Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.
Rodionov DA, Arzamasov AA, Khoroshkin MS, Iablokov SN, Leyn SA, Peterson SN, Novichkov PS, Osterman AL. Rodionov DA, et al. Among authors: leyn sa. Front Microbiol. 2019 Jun 12;10:1316. doi: 10.3389/fmicb.2019.01316. eCollection 2019. Front Microbiol. 2019. PMID: 31275260 Free PMC article.
37 results