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Page 1
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WG. Verlinde CL, et al. Among authors: larson et. Curr Top Med Chem. 2009;9(18):1678-87. doi: 10.2174/156802609790102383. Curr Top Med Chem. 2009. PMID: 19929835 Free PMC article. Review.
Prediction of protein crystallization outcome using a hybrid method.
Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Zucker FH, et al. Among authors: larson et. J Struct Biol. 2010 Jul;171(1):64-73. doi: 10.1016/j.jsb.2010.03.016. Epub 2010 Mar 27. J Struct Biol. 2010. PMID: 20347992 Free PMC article.
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Larson ET, et al. J Mol Biol. 2008 Sep 12;381(4):975-88. doi: 10.1016/j.jmb.2008.06.048. Epub 2008 Jun 24. J Mol Biol. 2008. PMID: 18602399 Free PMC article.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: larson et. Mol Biochem Parasitol. 2010 Feb;169(2):95-100. doi: 10.1016/j.molbiopara.2009.10.005. Epub 2009 Oct 27. Mol Biochem Parasitol. 2010. PMID: 19874856 Free PMC article.
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. Larson ET, et al. J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11. J Mol Biol. 2010. PMID: 20070944 Free PMC article.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG. Merritt EA, et al. Among authors: larson et. J Mol Biol. 2010 Mar 26;397(2):481-94. doi: 10.1016/j.jmb.2010.01.051. Epub 2010 Feb 2. J Mol Biol. 2010. PMID: 20132829 Free PMC article.
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC. Ojo KK, et al. Among authors: larson et. Nat Struct Mol Biol. 2010 May;17(5):602-7. doi: 10.1038/nsmb.1818. Epub 2010 May 2. Nat Struct Mol Biol. 2010. PMID: 20436472 Free PMC article.
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ. Johnson SM, et al. Among authors: larson et. J Med Chem. 2012 Mar 8;55(5):2416-26. doi: 10.1021/jm201713h. Epub 2012 Feb 27. J Med Chem. 2012. PMID: 22320388 Free PMC article.
54 results