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Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology.
Ben Toumia I, Bachetti T, Chekir-Ghedira L, Profumo A, Ponassi M, Di Domizio A, Izzotti A, Sciacca S, Puglisi C, Forte S, Giuffrida R, Colarossi C, Milardi D, Grasso G, Lanza V, Fiordoro S, Drago G, Tkachenko K, Cardinali B, Romano P, Iervasi E, Vargas GC, Barboro P, Kohnke FH, Rosano C. Ben Toumia I, et al. Among authors: lanza v. Front Pharmacol. 2024 Jan 3;14:1258108. doi: 10.3389/fphar.2023.1258108. eCollection 2023. Front Pharmacol. 2024. PMID: 38235113 Free PMC article.
Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.
Santoro AM, Lanza V, Bellia F, Sbardella D, Tundo GR, Cannizzo A, Grasso G, Arizzi M, Nicoletti VG, Alcaro S, Costa G, Pietropaolo A, Malgieri G, D'Abrosca G, Fattorusso R, García-Viñuales S, Ahmed IMM, Coletta M, Milardi D. Santoro AM, et al. Among authors: lanza v. ChemMedChem. 2020 Feb 5;15(3):302-316. doi: 10.1002/cmdc.201900612. Epub 2019 Dec 17. ChemMedChem. 2020. PMID: 31797568
126 results