LaPlante SR - Search Results

1

Robust Strategy for Hit-to-Lead Discovery: NMR for SAR.

Larda ST, Ayotte Y, Denk MM, Coote P, Heffron G, Bendahan D, Shahout F, Girard N, Iddir M, Bouchard P, Bilodeau F, Woo S, Farmer LJ, LaPlante SR. Larda ST, et al. Among authors: laplante sr. J Med Chem. 2023 Oct 12;66(19):13416-13427. doi: 10.1021/acs.jmedchem.3c00656. Epub 2023 Sep 21. J Med Chem. 2023. PMID: 37732695 Free PMC article.

2

Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.

Tsantrizos YS, Bolger G, Bonneau P, Cameron DR, Goudreau N, Kukolj G, LaPlante SR, Llinàs-Brunet M, Nar H, Lamarre D. Tsantrizos YS, et al. Among authors: laplante sr. Angew Chem Int Ed Engl. 2003 Mar 28;42(12):1356-60. doi: 10.1002/anie.200390347. Angew Chem Int Ed Engl. 2003. PMID: 12671967 No abstract available.

3

Human cytomegalovirus protease complexes its substrate recognition sequences in an extended peptide conformation.

LaPlante SR, Aubry N, Bonneau PR, Cameron DR, Lagacé L, Massariol MJ, Montpetit H, Plouffe C, Kawai SH, Fulton BD, Chen Z, Ni F. LaPlante SR, et al. Biochemistry. 1998 Jul 7;37(27):9793-801. doi: 10.1021/bi980555v. Biochemistry. 1998. PMID: 9657693

4

Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

LaPlante SR, Jakalian A, Aubry N, Bousquet Y, Ferland JM, Gillard J, Lefebvre S, Poirier M, Tsantrizos YS, Kukolj G, Beaulieu PL. LaPlante SR, et al. Angew Chem Int Ed Engl. 2004 Aug 20;43(33):4306-11. doi: 10.1002/anie.200460326. Angew Chem Int Ed Engl. 2004. PMID: 15368379 No abstract available.

5

The critical C-terminus of the small subunit of herpes simplex virus ribonucleotide reductase is mobile and conformationally similar to C-terminal peptides.

Laplante SR, Aubry N, Liuzzi M, Thelander L, Ingemarson R, Moss N. Laplante SR, et al. Int J Pept Protein Res. 1994 Dec;44(6):549-55. doi: 10.1111/j.1399-3011.1994.tb01143.x. Int J Pept Protein Res. 1994. PMID: 7705976

6

Toxin III of the scorpion Androctonus australis Hector: proton nuclear magnetic resonance assignments and secondary structure.

Mikou A, LaPlante SR, Guittet E, Lallemand JY, Martin-Eau Claire MF, Rochat H. Mikou A, et al. Among authors: laplante sr. J Biomol NMR. 1992 Jan;2(1):57-70. doi: 10.1007/BF02192800. J Biomol NMR. 1992. PMID: 1422146

7

Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.

McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G. McKercher G, et al. Nucleic Acids Res. 2004 Jan 22;32(2):422-31. doi: 10.1093/nar/gkh160. Print 2004. Nucleic Acids Res. 2004. PMID: 14739234 Free PMC article.

8

Alpha-cobratoxin: proton NMR assignments and solution structure.

Le Goas R, LaPlante SR, Mikou A, Delsuc MA, Guittet E, Robin M, Charpentier I, Lallemand JY. Le Goas R, et al. Among authors: laplante sr. Biochemistry. 1992 May 26;31(20):4867-75. doi: 10.1021/bi00135a018. Biochemistry. 1992. PMID: 1317211

9

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.

Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bös M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagacé L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinàs-Brunet M. Lamarre D, et al. Among authors: laplante sr. Nature. 2003 Nov 13;426(6963):186-9. doi: 10.1038/nature02099. Epub 2003 Oct 26. Nature. 2003. PMID: 14578911 Free article. Clinical Trial.

10

High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.

Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G. Tong L, et al. J Mol Biol. 1995 Jul 7;250(2):211-22. doi: 10.1006/jmbi.1995.0372. J Mol Biol. 1995. PMID: 7608971

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