Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy

Angew Chem Int Ed Engl. 2004 Aug 20;43(33):4306-11. doi: 10.1002/anie.200460326.
No abstract available

MeSH terms

  • Benzimidazoles / chemistry*
  • Benzimidazoles / pharmacology
  • Enzyme Inhibitors / chemistry
  • Hepacivirus / enzymology*
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Protein Binding
  • RNA-Dependent RNA Polymerase / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

  • Benzimidazoles
  • Enzyme Inhibitors
  • Viral Nonstructural Proteins
  • benzimidazole
  • NS-5 protein, hepatitis C virus
  • RNA-Dependent RNA Polymerase