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Revealing Drug Self-Associations into Nano-Entities.
Dlim MM, Shahout FS, Khabir MK, Labonté PP, LaPlante SR. Dlim MM, et al. Among authors: laplante sr. ACS Omega. 2019 May 23;4(5):8919-8925. doi: 10.1021/acsomega.9b00667. eCollection 2019 May 31. ACS Omega. 2019. PMID: 31459979 Free PMC article.
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
Mélin L, Abdullayev S, Fnaiche A, Vu V, González Suárez N, Zeng H, Szewczyk MM, Li F, Senisterra G, Allali-Hassani A, Chau I, Dong A, Woo S, Annabi B, Halabelian L, LaPlante SR, Vedadi M, Barsyte-Lovejoy D, Santhakumar V, Gagnon A. Mélin L, et al. Among authors: laplante sr. ChemMedChem. 2021 Oct 6;16(19):2982-3002. doi: 10.1002/cmdc.202100432. Epub 2021 Jul 28. ChemMedChem. 2021. PMID: 34164919
Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases.
Ayotte Y, Bernet E, Bilodeau F, Cimino M, Gagnon D, Lebughe M, Mistretta M, Ogadinma P, Ouali SL, Sow AA, Chatel-Chaix L, Descoteaux A, Manina G, Richard D, Veyrier F, LaPlante SR. Ayotte Y, et al. Among authors: laplante sr. ACS Chem Biol. 2021 Nov 19;16(11):2158-2163. doi: 10.1021/acschembio.1c00657. Epub 2021 Oct 26. ACS Chem Biol. 2021. PMID: 34699722
Jumping from Fragment to Drug via Smart Scaffolds.
Farahani MD, França TCC, Alapour S, Shahout F, Boulon R, Iddir M, Maddalena M, Ayotte Y, LaPlante SR. Farahani MD, et al. Among authors: laplante sr. ChemMedChem. 2022 May 18;17(10):e202200092. doi: 10.1002/cmdc.202200092. Epub 2022 Apr 1. ChemMedChem. 2022. PMID: 35298873
Robust Strategy for Hit-to-Lead Discovery: NMR for SAR.
Larda ST, Ayotte Y, Denk MM, Coote P, Heffron G, Bendahan D, Shahout F, Girard N, Iddir M, Bouchard P, Bilodeau F, Woo S, Farmer LJ, LaPlante SR. Larda ST, et al. Among authors: laplante sr. J Med Chem. 2023 Oct 12;66(19):13416-13427. doi: 10.1021/acs.jmedchem.3c00656. Epub 2023 Sep 21. J Med Chem. 2023. PMID: 37732695 Free PMC article.
93 results