LaPlante S - Search Results

1

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, Pesant M, Brochu C, Morin S, Chabot C, Halmos T, Bousquet Y, Bailey MD, Kawai SH, Coulombe R, LaPlante S, Jakalian A, Bhardwaj PK, Wernic D, Schroeder P, Amad M, Edwards P, Garneau M, Duan J, Cordingley M, Bethell R, Mason SW, Bös M, Bonneau P, Poupart MA, Faucher AM, Simoneau B, Fenwick C, Yoakim C, Tsantrizos Y. Fader LD, et al. Among authors: laplante s. ACS Med Chem Lett. 2014 Jan 22;5(4):422-7. doi: 10.1021/ml500002n. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900852 Free PMC article.

2

Evidence of a conformational change in the human cytomegalovirus protease upon binding of peptidyl-activated carbonyl inhibitors.

Bonneau PR, Grand-Maître C, Greenwood DJ, Lagacé L, LaPlante SR, Massariol MJ, Ogilvie WW, O'Meara JA, Kawai SH. Bonneau PR, et al. Among authors: laplante sr. Biochemistry. 1997 Oct 14;36(41):12644-52. doi: 10.1021/bi970366x. Biochemistry. 1997. PMID: 9376371

3

Peptide-based inhibitors of the hepatitis C virus serine protease.

Llinàs-Brunet M, Bailey M, Fazal G, Goulet S, Halmos T, Laplante S, Maurice R, Poirier M, Poupart MA, Thibeault D, Wernic D, Lamarre D. Llinàs-Brunet M, et al. Among authors: laplante s. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1713-8. doi: 10.1016/s0960-894x(98)00299-6. Bioorg Med Chem Lett. 1998. PMID: 9873421

4

NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain.

LaPlante SR, Aubry N, Bonneau PR, Kukolj G, Lamarre D, Lefebvre S, Li H, Llinàs-Brunet M, Plouffe C, Cameron DR. LaPlante SR, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2271-4. doi: 10.1016/s0960-894x(00)00466-2. Bioorg Med Chem Lett. 2000. PMID: 11055336

5

Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.

Tsantrizos YS, Bolger G, Bonneau P, Cameron DR, Goudreau N, Kukolj G, LaPlante SR, Llinàs-Brunet M, Nar H, Lamarre D. Tsantrizos YS, et al. Among authors: laplante sr. Angew Chem Int Ed Engl. 2003 Mar 28;42(12):1356-60. doi: 10.1002/anie.200390347. Angew Chem Int Ed Engl. 2003. PMID: 12671967 No abstract available.

6

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.

Lamarre D, Anderson PC, Bailey M, Beaulieu P, Bolger G, Bonneau P, Bös M, Cameron DR, Cartier M, Cordingley MG, Faucher AM, Goudreau N, Kawai SH, Kukolj G, Lagacé L, LaPlante SR, Narjes H, Poupart MA, Rancourt J, Sentjens RE, St George R, Simoneau B, Steinmann G, Thibeault D, Tsantrizos YS, Weldon SM, Yong CL, Llinàs-Brunet M. Lamarre D, et al. Among authors: laplante sr. Nature. 2003 Nov 13;426(6963):186-9. doi: 10.1038/nature02099. Epub 2003 Oct 26. Nature. 2003. PMID: 14578911 Free article. Clinical Trial.

7

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G. Beaulieu PL, et al. Among authors: laplante s. Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24. doi: 10.1016/j.bmcl.2003.10.023. Bioorg Med Chem Lett. 2004. PMID: 14684311

8

Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

LaPlante SR, Jakalian A, Aubry N, Bousquet Y, Ferland JM, Gillard J, Lefebvre S, Poirier M, Tsantrizos YS, Kukolj G, Beaulieu PL. LaPlante SR, et al. Angew Chem Int Ed Engl. 2004 Aug 20;43(33):4306-11. doi: 10.1002/anie.200460326. Angew Chem Int Ed Engl. 2004. PMID: 15368379 No abstract available.

9

RCM of tripeptide dienes containing a chiral vinylcyclopropane moiety: impact of different Ru-based catalysts on the stereochemical integrity of the macrocyclic products.

Poirier M, Aubry N, Boucher C, Ferland JM, LaPlante S, Tsantrizos YS. Poirier M, et al. Among authors: laplante s. J Org Chem. 2005 Dec 23;70(26):10765-73. doi: 10.1021/jo051706k. J Org Chem. 2005. PMID: 16355998

10

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G. Beaulieu PL, et al. Among authors: laplante s. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. doi: 10.1016/j.bmcl.2006.07.074. Bioorg Med Chem Lett. 2006. PMID: 16908138

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