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2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists.
Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D. Wang S, et al. Among authors: koskelainen t. Bioorg Med Chem Lett. 2022 Aug 1;69:128783. doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13. Bioorg Med Chem Lett. 2022. PMID: 35569686
Discovery and characterization of ORM-11372, a novel inhibitor of the sodium-calcium exchanger with positive inotropic activity.
Otsomaa L, Levijoki J, Wohlfahrt G, Chapman H, Koivisto AP, Syrjänen K, Koskelainen T, Peltokorpi SE, Finckenberg P, Heikkilä A, Abi-Gerges N, Ghetti A, Miller PE, Page G, Mervaala E, Nagy N, Kohajda Z, Jost N, Virág L, Varró A, Papp JG. Otsomaa L, et al. Among authors: koskelainen t. Br J Pharmacol. 2020 Dec;177(24):5534-5554. doi: 10.1111/bph.15257. Epub 2020 Nov 10. Br J Pharmacol. 2020. PMID: 32959887 Free PMC article.
Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.
Oravecz K, Kormos A, Gruber A, Márton Z, Kohajda Z, Mirzaei L, Jost N, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JG, Nánási PP, Antoons G, Varró A, Acsai K, Nagy N. Oravecz K, et al. Among authors: koskelainen t. Eur J Pharmacol. 2018 Jan 5;818:278-286. doi: 10.1016/j.ejphar.2017.10.039. Epub 2017 Oct 21. Eur J Pharmacol. 2018. PMID: 29066415 Free article.
ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart.
Jost N, Nagy N, Corici C, Kohajda Z, Horváth A, Acsai K, Biliczki P, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JG, Varró A, Virág L. Jost N, et al. Among authors: koskelainen t. Br J Pharmacol. 2013 Oct;170(4):768-78. doi: 10.1111/bph.12228. Br J Pharmacol. 2013. PMID: 23647096 Free PMC article.
The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.
Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L. Kohajda Z, et al. Among authors: koskelainen t. PLoS One. 2016 Nov 10;11(11):e0166041. doi: 10.1371/journal.pone.0166041. eCollection 2016. PLoS One. 2016. PMID: 27832106 Free PMC article.
Association of Modic changes with health-related quality of life among patients referred to spine surgery.
Määttä J, Kautiainen H, Leinonen V, Niinimäki J, Järvenpää S, Koskelainen T, Mäkelä P, Pesälä J, Nyyssönen T, Savolainen S, Airaksinen O, Kyllönen E, Cheung KMC, Karppinen J. Määttä J, et al. Among authors: koskelainen t. Scand J Pain. 2014 Jan 1;5(1):36-40. doi: 10.1016/j.sjpain.2013.08.003. Scand J Pain. 2014. PMID: 29913663 Free article.
Early rebleeding after coiling of ruptured intracranial aneurysms.
Jartti P, Isokangas JM, Karttunen A, Jartti A, Haapea M, Koskelainen T, Tervonen O. Jartti P, et al. Among authors: koskelainen t. Acta Radiol. 2010 Nov;51(9):1043-9. doi: 10.3109/02841851.2010.508172. Acta Radiol. 2010. PMID: 20849318