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Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis.
Biesemann N, Margerie D, Asbrand C, Rehberg M, Savova V, Agueusop I, Klemmer D, Ding-Pfennigdorff D, Schwahn U, Dudek M, Heyninck K, De Tavernier E, Cornelis S, Kohlmann M, Nestle FO, Herrmann M. Biesemann N, et al. Among authors: kohlmann m. Sci Transl Med. 2023 Feb;15(681):eabq4419. doi: 10.1126/scitranslmed.abq4419. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724239
An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.
Vugler A, O'Connell J, Nguyen MA, Weitz D, Leeuw T, Hickford E, Verbitsky A, Ying X, Rehberg M, Carrington B, Merriman M, Moss A, Nicholas JM, Stanley P, Wright S, Bourne T, Foricher Y, Brookings D, Horsley H, Herrmann M, Rao S, Kohlmann M, Florian P. Vugler A, et al. Among authors: kohlmann m. Front Pharmacol. 2022 Nov 16;13:1037983. doi: 10.3389/fphar.2022.1037983. eCollection 2022. Front Pharmacol. 2022. PMID: 36467083 Free PMC article.
Performance characteristics of a polymerase chain reaction-based assay for the detection of EGFR mutations in plasma cell-free DNA from patients with non-small cell lung cancer using cell-free DNA collection tubes.
May T, Clement MS, Halait H, Kohlmann A, Kohlmann M, Lai J, Lee N, Li-Sucholeiki X, Meldgaard P, Joshi S, Scudder S, Shrestha N, Sorensen B, Kiral M, O'Donnell P. May T, et al. Among authors: kohlmann m. PLoS One. 2024 Apr 9;19(4):e0295987. doi: 10.1371/journal.pone.0295987. eCollection 2024. PLoS One. 2024. PMID: 38593164 Free PMC article.
A Brief Report of Durvalumab With or Without Tremelimumab in Combination With Chemotherapy as First-Line Therapy for Metastatic Non-Small-Cell Lung Cancer: Outcomes by Tumor PD-L1 Expression in the Phase 3 POSEIDON Study.
Garon EB, Cho BC, Luft A, Alatorre-Alexander J, Geater SL, Trukhin D, Kim SW, Ursol G, Hussein M, Lim FL, Yang CT, Araujo LH, Saito H, Reinmuth N, Kohlmann M, Lowery C, Mann H, Peters S, Mok TS, Johnson ML. Garon EB, et al. Among authors: kohlmann m. Clin Lung Cancer. 2024 May;25(3):266-273.e5. doi: 10.1016/j.cllc.2024.03.003. Epub 2024 Mar 15. Clin Lung Cancer. 2024. PMID: 38584069 Free article. Clinical Trial. No abstract available.
Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
Ackerson T, Amberg A, Atzrodt J, Arabeyre C, Defossa E, Dorau M, Dudda A, Dwyer J, Holla W, Kissner T, Kohlmann M, Kürzel U, Pánczél J, Rajanna S, Riedel J, Schmidt F, Wäse K, Weitz D, Derdau V. Ackerson T, et al. Among authors: kohlmann m. J Biochem Mol Toxicol. 2019 Aug;33(8):e22345. doi: 10.1002/jbt.22345. Epub 2019 May 8. J Biochem Mol Toxicol. 2019. PMID: 31066974
Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.
Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Qiu J, et al. Among authors: kohlmann m. Amino Acids. 2019 Jan;51(1):7-16. doi: 10.1007/s00726-018-2601-z. Epub 2018 Jun 20. Amino Acids. 2019. PMID: 29922921
In vivo visualization of osteoarthritic hypertrophic lesions.
Hu HY, Lim NH, Juretschke HP, Ding-Pfennigdorff D, Florian P, Kohlmann M, Kandira A, Peter von Kries J, Saas J, Rudolphi KA, Wendt KU, Nagase H, Plettenburg O, Nazare M, Schultz C. Hu HY, et al. Among authors: kohlmann m. Chem Sci. 2015 Nov 1;6(11):6256-6261. doi: 10.1039/c5sc01301a. Epub 2015 Aug 12. Chem Sci. 2015. PMID: 30090244 Free PMC article.
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.
Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, König C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Müller R. Kling A, et al. Among authors: kohlmann m. Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690. Science. 2015. PMID: 26045430
38 results