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Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.
Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra S, Mohapatra S, Haraszti RA, Khvorova A, Aronin N, Sava V. Sanchez-Ramos J, et al. Among authors: khvorova a. J Drug Deliv Sci Technol. 2018 Feb;43:453-460. doi: 10.1016/j.jddst.2017.11.013. Epub 2017 Nov 21. J Drug Deliv Sci Technol. 2018. PMID: 29805475 Free PMC article.
Taking charge of siRNA delivery.
Khvorova A, Osborn MF, Hassler MR. Khvorova A, et al. Nat Biotechnol. 2014 Dec;32(12):1197-8. doi: 10.1038/nbt.3091. Nat Biotechnol. 2014. PMID: 25489835
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Godinho BMDC, Gilbert JW, Haraszti RA, Coles AH, Biscans A, Roux L, Nikan M, Echeverria D, Hassler M, Khvorova A. Godinho BMDC, et al. Among authors: khvorova a. Nucleic Acid Ther. 2017 Dec;27(6):323-334. doi: 10.1089/nat.2017.0690. Epub 2017 Oct 12. Nucleic Acid Ther. 2017. PMID: 29022758 Free PMC article.
Improving siRNA Delivery In Vivo Through Lipid Conjugation.
Osborn MF, Khvorova A. Osborn MF, et al. Among authors: khvorova a. Nucleic Acid Ther. 2018 Jun;28(3):128-136. doi: 10.1089/nat.2018.0725. Epub 2018 May 10. Nucleic Acid Ther. 2018. PMID: 29746209 Free PMC article. Review.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Godinho BMDC, Henninger N, Bouley J, Alterman JF, Haraszti RA, Gilbert JW, Sapp E, Coles AH, Biscans A, Nikan M, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Godinho BMDC, et al. Among authors: khvorova a. Mol Ther. 2018 Nov 7;26(11):2580-2591. doi: 10.1016/j.ymthe.2018.08.005. Epub 2018 Aug 8. Mol Ther. 2018. PMID: 30143435 Free PMC article.
142 results