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Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.
Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I, Endermann T, Zasada C, Apostolova I, Gerling M, Kempa S, Hughes R, Lewis CE, Brenner W, Malinowski MB, Stockmann M, Schomburg L, Faller W, Sansom OJ, Tacke F, Morkel M, Cramer T. Rohwer N, et al. Among authors: kempa s. Oncogene. 2019 Jul;38(28):5670-5685. doi: 10.1038/s41388-019-0816-4. Epub 2019 May 1. Oncogene. 2019. PMID: 31043706 Free article.
Spatiotemporal, optogenetic control of gene expression in organoids.
Legnini I, Emmenegger L, Zappulo A, Rybak-Wolf A, Wurmus R, Martinez AO, Jara CC, Boltengagen A, Hessler T, Mastrobuoni G, Kempa S, Zinzen R, Woehler A, Rajewsky N. Legnini I, et al. Among authors: kempa s. Nat Methods. 2023 Oct;20(10):1544-1552. doi: 10.1038/s41592-023-01986-w. Epub 2023 Sep 21. Nat Methods. 2023. PMID: 37735569 Free PMC article.
Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T. Rohwer N, et al. Among authors: kempa s. Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793. Oncotarget. 2016. PMID: 26760764 Free PMC article.
Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer.
Berndt N, Egners A, Mastrobuoni G, Vvedenskaya O, Fragoulis A, Dugourd A, Bulik S, Pietzke M, Bielow C, van Gassel R, Damink SWO, Erdem M, Saez-Rodriguez J, Holzhütter HG, Kempa S, Cramer T. Berndt N, et al. Among authors: kempa s. Br J Cancer. 2020 Jan;122(2):233-244. doi: 10.1038/s41416-019-0659-3. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819186 Free PMC article.
Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
Arlt B, Zasada C, Baum K, Wuenschel J, Mastrobuoni G, Lodrini M, Astrahantseff K, Winkler A, Schulte JH, Finkler S, Forbes M, Hundsdoerfer P, Guergen D, Hoffmann J, Wolf J, Eggert A, Kempa S, Deubzer HE. Arlt B, et al. Among authors: kempa s. Int J Cancer. 2021 Mar 1;148(5):1219-1232. doi: 10.1002/ijc.33423. Epub 2020 Dec 17. Int J Cancer. 2021. PMID: 33284994 Free article.
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S, Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA. Dörr JR, et al. Among authors: kempa s. Nature. 2013 Sep 19;501(7467):421-5. doi: 10.1038/nature12437. Epub 2013 Aug 14. Nature. 2013. PMID: 23945590
113 results