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Impact of heparanase-2 (Hpa2) on cancer and inflammation: Advances and paradigms.
FASEB J. 2024 May 31;38(10):e23670. doi: 10.1096/fj.202400286R.
FASEB J. 2024.
PMID: 38747803
Review.
Heparanase-A single protein with multiple enzymatic and nonenzymatic functions.
Vlodavsky I, Kayal Y, Hilwi M, Soboh S, Sanderson RD, Ilan N.
Vlodavsky I, et al. Among authors: kayal y.
Proteoglycan Res. 2023 Jul 1;1(3):e6. doi: 10.1002/pgr2.6. Epub 2023 Jul 9.
Proteoglycan Res. 2023.
PMID: 37547889
Free PMC article.
Review.
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Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation.
Kayal Y, Barash U, Naroditsky I, Ilan N, Vlodavsky I.
Kayal Y, et al.
Cell Death Dis. 2023 Jul 25;14(7):465. doi: 10.1038/s41419-023-05990-y.
Cell Death Dis. 2023.
PMID: 37491420
Free PMC article.
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Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase.
Doherty GG, Ler GJM, Wimmer N, Bernhardt PV, Ashmus RA, Vocadlo DJ, Armstrong Z, Davies GJ, Maccarana M, Li JP, Kayal Y, Ferro V.
Doherty GG, et al. Among authors: kayal y.
Chembiochem. 2023 Feb 14;24(4):e202200619. doi: 10.1002/cbic.202200619. Epub 2023 Jan 3.
Chembiochem. 2023.
PMID: 36453606
Free article.
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Heparin-Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications.
Massironi N, Colombo M, Cosentino C, Fiandra L, Mauri M, Kayal Y, Testa F, Torri G, Urso E, Vismara E, Vlodavsky I.
Massironi N, et al. Among authors: kayal y.
Molecules. 2022 Oct 21;27(20):7116. doi: 10.3390/molecules27207116.
Molecules. 2022.
PMID: 36296711
Free PMC article.
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Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.
de Boer C, Armstrong Z, Lit VAJ, Barash U, Ruijgrok G, Boyango I, Weitzenberg MM, Schröder SP, Sarris AJC, Meeuwenoord NJ, Bule P, Kayal Y, Ilan N, Codée JDC, Vlodavsky I, Overkleeft HS, Davies GJ, Wu L.
de Boer C, et al. Among authors: kayal y.
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203167119. doi: 10.1073/pnas.2203167119. Epub 2022 Jul 26.
Proc Natl Acad Sci U S A. 2022.
PMID: 35881786
Free PMC article.
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Heparan Sulfate Mimicking Glycopolymer Prevents Pancreatic β Cell Destruction and Suppresses Inflammatory Cytokine Expression in Islets under the Challenge of Upregulated Heparanase.
Loka RS, Song Z, Sletten ET, Kayal Y, Vlodavsky I, Zhang K, Nguyen HM.
Loka RS, et al. Among authors: kayal y.
ACS Chem Biol. 2022 Jun 17;17(6):1387-1400. doi: 10.1021/acschembio.1c00908. Epub 2022 Jun 4.
ACS Chem Biol. 2022.
PMID: 35658404
Free PMC article.
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Heparanase 2 (Hpa2) attenuates the growth of pancreatic carcinoma.
Kayal Y, Singh P, Naroditsky I, Ilan N, Vlodavsky I.
Kayal Y, et al.
Matrix Biol. 2021 Apr;98:21-31. doi: 10.1016/j.matbio.2021.03.002. Epub 2021 Apr 8.
Matrix Biol. 2021.
PMID: 33839221
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