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Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists.
Bioorg Med Chem Lett. 2022 Dec 1;77:129005. doi: 10.1016/j.bmcl.2022.129005. Epub 2022 Sep 26.
Bioorg Med Chem Lett. 2022.
PMID: 36174834
2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists.
Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D.
Wang S, et al. Among authors: kaskinoro j.
Bioorg Med Chem Lett. 2022 Aug 1;69:128783. doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13.
Bioorg Med Chem Lett. 2022.
PMID: 35569686
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GABAB receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine.
de Miguel E, Vekovischeva O, Kuokkanen K, Vesajoki M, Paasikoski N, Kaskinoro J, Myllymäki M, Lainiola M, Janhunen SK, Hyytiä P, Linden AM, Korpi ER.
de Miguel E, et al. Among authors: kaskinoro j.
Addict Biol. 2019 Nov;24(6):1191-1203. doi: 10.1111/adb.12688. Epub 2018 Nov 13.
Addict Biol. 2019.
PMID: 30421860
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Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats.
Lamminen T, Doedée A, Hyttilä-Hopponen M, Kaskinoro J.
Lamminen T, et al. Among authors: kaskinoro j.
J Vet Pharmacol Ther. 2022 Jul;45(4):385-391. doi: 10.1111/jvp.13061. Epub 2022 Apr 25.
J Vet Pharmacol Ther. 2022.
PMID: 35466408
Free PMC article.
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Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.
Shojaei M, Zhou Q, Palumbo G, Schaefer R, Kaskinoro J, Vehmaan-Kreula P, Bartenstein P, Brendel M, Edbauer D, Lindner S.
Shojaei M, et al. Among authors: kaskinoro j.
ACS Pharmacol Transl Sci. 2024 Apr 25;7(5):1404-1414. doi: 10.1021/acsptsci.4c00037. eCollection 2024 May 10.
ACS Pharmacol Transl Sci. 2024.
PMID: 38751620
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Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain.
Jalava N, Kaskinoro J, Chapman H, Morales M, Metsänkylä H, Heinonen SM, Koivisto AP.
Jalava N, et al. Among authors: kaskinoro j.
Int J Mol Sci. 2023 Feb 8;24(4):3350. doi: 10.3390/ijms24043350.
Int J Mol Sci. 2023.
PMID: 36834762
Free PMC article.
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Ocular Administration of Palonosetron in the Prevention of Cisplatin-Induced Nausea and Vomiting.
Levijoki J, Saloranta L, Tuunainen J, Kaskinoro J, Pappinen S, Nourry S, Betat AM, Maurin A, Pakarinen M, Häkkinen S, Tervapuro J, Pihlasvaara H, Drieu La Rochelle C, Joensuu H.
Levijoki J, et al. Among authors: kaskinoro j.
J Pharmacol Exp Ther. 2023 Mar;384(3):439-444. doi: 10.1124/jpet.122.001444. Epub 2023 Jan 12.
J Pharmacol Exp Ther. 2023.
PMID: 36635086
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