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Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.
Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Becker-Pauly C, et al. Among authors: kappelhoff r. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. doi: 10.1074/mcp.M111.009233. Epub 2011 Jun 21. Mol Cell Proteomics. 2011. PMID: 21693781 Free PMC article.
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.
Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Eckhard U, et al. Among authors: kappelhoff r. Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25. Matrix Biol. 2016. PMID: 26407638 Free article.
Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing.
Yiallouros I, Kappelhoff R, Schilling O, Wegmann F, Helms MW, Auge A, Brachtendorf G, Berkhoff EG, Beermann B, Hinz HJ, König S, Peter-Katalinic J, Stöcker W. Yiallouros I, et al. Among authors: kappelhoff r. J Mol Biol. 2002 Nov 22;324(2):237-46. doi: 10.1016/s0022-2836(02)01102-6. J Mol Biol. 2002. PMID: 12441103
Proenzyme structure and activation of astacin metallopeptidase.
Guevara T, Yiallouros I, Kappelhoff R, Bissdorf S, Stöcker W, Gomis-Rüth FX. Guevara T, et al. Among authors: kappelhoff r. J Biol Chem. 2010 Apr 30;285(18):13958-65. doi: 10.1074/jbc.M109.097436. Epub 2010 Mar 4. J Biol Chem. 2010. PMID: 20202938 Free PMC article.
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.
Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Eckhard U, et al. Among authors: kappelhoff r. Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun. Data Brief. 2016. PMID: 26981551 Free PMC article.
Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray.
Kappelhoff R, Puente XS, Wilson CH, Seth A, López-Otín C, Overall CM. Kappelhoff R, et al. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2210-2219. doi: 10.1016/j.bbamcr.2017.08.004. Epub 2017 Aug 7. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28797648 Free article. Review.
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