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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: kuhne r. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Opitz R, Müller M, Reuter C, Barone M, Soicke A, Roske Y, Piotukh K, Huy P, Beerbaum M, Wiesner B, Beyermann M, Schmieder P, Freund C, Volkmer R, Oschkinat H, Schmalz HG, Kühne R. Opitz R, et al. Among authors: kuhne r. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6. doi: 10.1073/pnas.1422054112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848013 Free PMC article.
Design of N-substituted peptomer ligands for EVH1 domains.
Zimmermann J, Kühne R, Volkmer-Engert R, Jarchau T, Walter U, Oschkinat H, Ball LJ. Zimmermann J, et al. Among authors: kuhne r. J Biol Chem. 2003 Sep 19;278(38):36810-8. doi: 10.1074/jbc.M305934200. Epub 2003 Jul 10. J Biol Chem. 2003. PMID: 12857736 Free article.
Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.
Zaminer J, Brockmann C, Huy P, Opitz R, Reuter C, Beyermann M, Freund C, Müller M, Oschkinat H, Kühne R, Schmalz HG. Zaminer J, et al. Among authors: kuhne r. Angew Chem Int Ed Engl. 2010 Sep 17;49(39):7111-5. doi: 10.1002/anie.201001739. Angew Chem Int Ed Engl. 2010. PMID: 20803590 No abstract available.
126 results