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Real-world application of PBPK in drug discovery.
Santos LGA, Jaiswal S, Chen KF, Jones HM, Templeton IE. Santos LGA, et al. Among authors: jones hm. Drug Metab Dispos. 2023 Dec 12:DMD-MR-2022-001036. doi: 10.1124/dmd.122.001036. Online ahead of print. Drug Metab Dispos. 2023. PMID: 38123941 Free article.
Development and application of a PBPK modeling strategy to support antimalarial drug development.
Abla N, Howgate E, Rowland-Yeo K, Dickins M, Bergagnini-Kolev MC, Chen KF, McFeely S, Bonner JJ, Santos LGA, Gobeau N, Burt H, Barter Z, Jones HM, Wesche D, Charman SA, Möhrle JJ, Burrows JN, Almond LM. Abla N, et al. Among authors: jones hm. CPT Pharmacometrics Syst Pharmacol. 2023 Sep;12(9):1335-1346. doi: 10.1002/psp4.13013. Epub 2023 Aug 16. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37587640 Free PMC article.
Tiered approach to evaluate the CYP3A victim and perpetrator drug-drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling.
Mulford DJ, Ramsden D, Zhang L, Michon I, Leifke E, Smith N, Jones HM, Scarpignato C. Mulford DJ, et al. Among authors: jones hm. CPT Pharmacometrics Syst Pharmacol. 2023 Apr;12(4):532-544. doi: 10.1002/psp4.12939. Epub 2023 Mar 10. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36896795 Free PMC article.
A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
Yang Z, Rioux N, Vincent L, Jones HM, Cha D, Plummer A, Wilfret D, Kearney BP. Yang Z, et al. Among authors: jones hm. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1553-1564. doi: 10.1002/psp4.13034. Epub 2023 Aug 30. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37614073 Free PMC article.
293 results