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Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody.
Staflin K, Zuch de Zafra CL, Schutt LK, Clark V, Zhong F, Hristopoulos M, Clark R, Li J, Mathieu M, Chen X, Johnston J, Low J, Ybarra R, Slaga D, Yang J, Ovacik M, Dybdal NO, Totpal K, Junttila MR, Ellerman D, Lee G, Dennis MS, Prell R, Junttila TT. Staflin K, et al. Among authors: johnston j. JCI Insight. 2020 Apr 9;5(7):e133757. doi: 10.1172/jci.insight.133757. JCI Insight. 2020. PMID: 32271166 Free PMC article.
Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells.
Junttila TT, Li J, Johnston J, Hristopoulos M, Clark R, Ellerman D, Wang BE, Li Y, Mathieu M, Li G, Young J, Luis E, Lewis Phillips G, Stefanich E, Spiess C, Polson A, Irving B, Scheer JM, Junttila MR, Dennis MS, Kelley R, Totpal K, Ebens A. Junttila TT, et al. Among authors: johnston j. Cancer Res. 2014 Oct 1;74(19):5561-71. doi: 10.1158/0008-5472.CAN-13-3622-T. Epub 2014 Sep 16. Cancer Res. 2014. PMID: 25228655
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing.
Li J, Stagg NJ, Johnston J, Harris MJ, Menzies SA, DiCara D, Clark V, Hristopoulos M, Cook R, Slaga D, Nakamura R, McCarty L, Sukumaran S, Luis E, Ye Z, Wu TD, Sumiyoshi T, Danilenko D, Lee GY, Totpal K, Ellerman D, Hötzel I, James JR, Junttila TT. Li J, et al. Among authors: johnston j. Cancer Cell. 2017 Mar 13;31(3):383-395. doi: 10.1016/j.ccell.2017.02.001. Epub 2017 Mar 2. Cancer Cell. 2017. PMID: 28262555 Free PMC article.
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer.
Lo AA, Johnston J, Li J, Mandikian D, Hristopoulos M, Clark R, Nickles D, Liang WC, Hötzel K, Dunlap D, Pham T, Cai H, Ovacik M, Bravo-Perez D, Mai E, Slaga D, Ellerman D, Ziai J, Totpal K, Lee G, Boswell CA, Payandeh J, Wu Y, Junttila TT. Lo AA, et al. Among authors: johnston j. Mol Cancer Ther. 2021 Apr;20(4):716-725. doi: 10.1158/1535-7163.MCT-20-0490. Epub 2021 Feb 3. Mol Cancer Ther. 2021. PMID: 33536191
Genome assembly of the southern pine beetle ( Dendroctonus frontalis Zimmerman) reveals the origins of gene content reduction in Dendroctonus.
Copeland M, Landa S, Owoyemi A, Jonika MM, Alfieri J, Sylvester T, Hoover Z, Hjelmen CE, Johnston JS, Kyre BR, Rieske LK, Blackmon H, Casola C. Copeland M, et al. Among authors: johnston js. bioRxiv [Preprint]. 2024 May 10:2024.05.08.592785. doi: 10.1101/2024.05.08.592785. bioRxiv. 2024. PMID: 38766115 Free PMC article. Preprint.
A cytomics-on-a-chip platform and diagnostic model stratifies risk for oral lichenoid conditions.
McRae MP, Srinivasan Rajsri K, Ross Kerr A, Vigneswaran N, Redding SW, Janal M, Kang SK, Palomo L, Christodoulides NJ, Singh M, Johnston J, McDevitt JT. McRae MP, et al. Among authors: johnston j. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 Apr 15:S2212-4403(24)00155-X. doi: 10.1016/j.oooo.2024.04.003. Online ahead of print. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024. PMID: 38755071
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.
Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A, Lin CY, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE. Huang Q, et al. Among authors: johnston j. Science. 2024 May 16:eadm8386. doi: 10.1126/science.adm8386. Online ahead of print. Science. 2024. PMID: 38753766
4,218 results