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Page 1
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C. Newton GK, et al. Among authors: jenkins k. J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17. J Med Chem. 2014. PMID: 25365789 Free PMC article.
Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Zhang J, Chen J, Richardson JP, Francis-Newton NJ, Lai PF, Jenkins K, Major MR, Key RE, Stewart ME, Firth-Clark S, Lloyd SM, Newton GK, Perrior TR, Garrod DR, Robinson C. Zhang J, et al. Among authors: jenkins k. ACS Pharmacol Transl Sci. 2022 Aug 12;5(9):735-751. doi: 10.1021/acsptsci.2c00022. eCollection 2022 Sep 9. ACS Pharmacol Transl Sci. 2022. PMID: 36110379 Free PMC article.
Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
Perry B, Alexander R, Bennett G, Buckley G, Ceska T, Crabbe T, Dale V, Gowers L, Horsley H, James L, Jenkins K, Crépy K, Kulisa C, Lightfoot H, Lock C, Mack S, Morgan T, Nicolas AL, Pitt W, Sabin V, Wright S. Perry B, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4700-4. doi: 10.1016/j.bmcl.2008.06.104. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18644721
Optimization of a series of multi-isoform PI3 kinase inhibitors.
Perry B, Beevers R, Bennett G, Buckley G, Crabbe T, Gowers L, James L, Jenkins K, Lock C, Sabin V, Wright S. Perry B, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5299-302. doi: 10.1016/j.bmcl.2008.08.042. Epub 2008 Aug 20. Bioorg Med Chem Lett. 2008. PMID: 18774713
IRAK-4 inhibitors. Part 1: a series of amides.
Buckley GM, Gowers L, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V, Fraser JL. Buckley GM, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. doi: 10.1016/j.bmcl.2008.04.058. Epub 2008 Apr 26. Bioorg Med Chem Lett. 2008. PMID: 18474425
IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.
Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039. Epub 2008 Apr 22. Bioorg Med Chem Lett. 2008. PMID: 18482836
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
Ahmed S, Ayscough A, Barker GR, Canning HE, Davenport R, Downham R, Harrison D, Jenkins K, Kinsella N, Livermore DG, Wright S, Ivetac AD, Skene R, Wilkens SJ, Webster NA, Hendrick AG. Ahmed S, et al. Among authors: jenkins k. J Med Chem. 2017 Jul 13;60(13):5663-5672. doi: 10.1021/acs.jmedchem.7b00352. Epub 2017 Jun 24. J Med Chem. 2017. PMID: 28594552
IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V. Buckley GM, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. doi: 10.1016/j.bmcl.2008.04.042. Epub 2008 Apr 24. Bioorg Med Chem Lett. 2008. PMID: 18501603
Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Beevers RE, Buckley GM, Davies N, Fraser JL, Galvin FC, Hannah DR, Haughan AF, Jenkins K, Mack SR, Pitt WR, Ratcliffe AJ, Richard MD, Sabin V, Sharpe A, Williams SC. Beevers RE, et al. Among authors: jenkins k. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. doi: 10.1016/j.bmcl.2006.01.090. Epub 2006 Feb 17. Bioorg Med Chem Lett. 2006. PMID: 16483773
784 results