Optimization of a series of multi-isoform PI3 kinase inhibitors

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5299-302. doi: 10.1016/j.bmcl.2008.08.042. Epub 2008 Aug 20.

Abstract

Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.

MeSH terms

  • Administration, Oral
  • Animals
  • Benzoxazines / chemical synthesis*
  • Benzoxazines / chemistry
  • Benzoxazines / pharmacology*
  • Combinatorial Chemistry Techniques
  • Inhibitory Concentration 50
  • Isoenzymes / antagonists & inhibitors
  • Male
  • Molecular Structure
  • Phosphoinositide-3 Kinase Inhibitors*
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Rats
  • Rats, Wistar
  • Structure-Activity Relationship

Substances

  • Benzoxazines
  • Isoenzymes
  • Phosphoinositide-3 Kinase Inhibitors
  • Pyrazoles