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Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms.
Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Andersen JB, et al. Among authors: jansen cu. NPJ Biofilms Microbiomes. 2021 Jul 9;7(1):59. doi: 10.1038/s41522-021-00225-4. NPJ Biofilms Microbiomes. 2021. PMID: 34244523 Free PMC article.
Convergent Total Synthesis of Exochelin 772SM.
Jansen CU, Nørskov A, Mortensen KT, Qvortrup KM. Jansen CU, et al. J Org Chem. 2023 Jul 7;88(13):8669-8673. doi: 10.1021/acs.joc.3c00561. Epub 2023 Jun 9. J Org Chem. 2023. PMID: 37294812
Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump.
Kristensen R, Andersen JB, Rybtke M, Jansen CU, Fritz BG, Kiilerich RO, Uhd J, Bjarnsholt T, Qvortrup K, Tolker-Nielsen T, Givskov M, Jakobsen TH. Kristensen R, et al. Among authors: jansen cu. Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0138723. doi: 10.1128/aac.01387-23. Epub 2024 Jan 8. Antimicrob Agents Chemother. 2024. PMID: 38189278 Free PMC article.
Chemoenzymatic indican for light-driven denim dyeing.
Bidart GN, Teze D, Jansen CU, Pasutto E, Putkaradze N, Sesay AM, Fredslund F, Lo Leggio L, Ögmundarson O, Sukumara S, Qvortrup K, Welner DH. Bidart GN, et al. Among authors: jansen cu. Nat Commun. 2024 Feb 27;15(1):1489. doi: 10.1038/s41467-024-45749-3. Nat Commun. 2024. PMID: 38413572 Free PMC article.
High efficacy treatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilm compound Disperazol in combination with ciprofloxacin.
Hultqvist LD, Andersen JB, Nilsson CM, Jansen CU, Rybtke M, Jakobsen TH, Nielsen TE, Qvortrup K, Moser C, Graz M, Qvortrup K, Tolker-Nielsen T, Givskov M. Hultqvist LD, et al. Among authors: jansen cu. Antimicrob Agents Chemother. 2024 May 8:e0148123. doi: 10.1128/aac.01481-23. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38717093