Iyer P - Search Results

1

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation.

Parafati M, Bae SH, Kirby RJ, Fitzek M, Iyer P, Engkvist O, Smith DM, Malany S. Parafati M, et al. Among authors: iyer p. Int J Mol Sci. 2020 Dec 15;21(24):9557. doi: 10.3390/ijms21249557. Int J Mol Sci. 2020. PMID: 33334026 Free PMC article.

2

Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development.

Davis AM, Engkvist O, Fairclough RJ, Feierberg I, Freeman A, Iyer P. Davis AM, et al. Among authors: iyer p. SLAS Discov. 2021 Jun;26(5):604-619. doi: 10.1177/2472555220982268. Epub 2021 Feb 13. SLAS Discov. 2021. PMID: 33586501 Free article. Review.

3

MAIP: a web service for predicting blood-stage malaria inhibitors.

Bosc N, Felix E, Arcila R, Mendez D, Saunders MR, Green DVS, Ochoada J, Shelat AA, Martin EJ, Iyer P, Engkvist O, Verras A, Duffy J, Burrows J, Gardner JMF, Leach AR. Bosc N, et al. Among authors: iyer p. J Cheminform. 2021 Feb 22;13(1):13. doi: 10.1186/s13321-021-00487-2. J Cheminform. 2021. PMID: 33618772 Free PMC article.

4

SAR monitoring of evolving compound data sets using activity landscapes.

Iyer P, Hu Y, Bajorath J. Iyer P, et al. J Chem Inf Model. 2011 Mar 28;51(3):532-40. doi: 10.1021/ci100505m. Epub 2011 Feb 15. J Chem Inf Model. 2011. PMID: 21322535

5

Nuclear fascin regulates cancer cell survival.

Lawson CD, Peel S, Jayo A, Corrigan A, Iyer P, Baxter Dalrymple M, Marsh RJ, Cox S, Van Audenhove I, Gettemans J, Parsons M. Lawson CD, et al. Among authors: iyer p. Elife. 2022 Aug 30;11:e79283. doi: 10.7554/eLife.79283. Elife. 2022. PMID: 36039640 Free PMC article.

6

Rationalizing three-dimensional activity landscapes and the influence of molecular representations on landscape topology and the formation of activity cliffs.

Peltason L, Iyer P, Bajorath J. Peltason L, et al. Among authors: iyer p. J Chem Inf Model. 2010 Jun 28;50(6):1021-33. doi: 10.1021/ci100091e. J Chem Inf Model. 2010. PMID: 20443603

7

Molecular mechanism-based network-like similarity graphs reveal relationships between different types of receptor ligands and structural changes that determine agonistic, inverse-agonistic, and antagonistic effects.

Iyer P, Stumpfe D, Bajorath J. Iyer P, et al. J Chem Inf Model. 2011 Jun 27;51(6):1281-6. doi: 10.1021/ci2001378. Epub 2011 May 18. J Chem Inf Model. 2011. PMID: 21548655

8

Extraction of discontinuous structure-activity relationships from compound data sets through particle swarm optimization.

Namasivayam V, Iyer P, Bajorath J. Namasivayam V, et al. Among authors: iyer p. J Chem Inf Model. 2011 Jul 25;51(7):1545-51. doi: 10.1021/ci2001692. Epub 2011 Jun 24. J Chem Inf Model. 2011. PMID: 21644503

9

Representation of multi-target activity landscapes through target pair-based compound encoding in self-organizing maps.

Iyer P, Bajorath J. Iyer P, et al. Chem Biol Drug Des. 2011 Nov;78(5):778-86. doi: 10.1111/j.1747-0285.2011.01235.x. Epub 2011 Oct 5. Chem Biol Drug Des. 2011. PMID: 21895984

10

Exploring SAR continuity in the vicinity of activity cliffs.

Namasivayam V, Iyer P, Bajorath J. Namasivayam V, et al. Among authors: iyer p. Chem Biol Drug Des. 2012 Jan;79(1):22-9. doi: 10.1111/j.1747-0285.2011.01256.x. Epub 2011 Nov 8. Chem Biol Drug Des. 2012. PMID: 21985661

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