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Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.
Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li-Ma C, Ko Y, Lander GC, Wiseman RL, Bollong MJ. Ibrahim L, et al. Cell Chem Biol. 2023 Oct 19;30(10):1295-1302.e4. doi: 10.1016/j.chembiol.2023.07.014. Epub 2023 Aug 23. Cell Chem Biol. 2023. PMID: 37619563
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko Y, Hong M, Lee S, Kumar M, Ibrahim L, Nutsch K, Stanton C, Sondermann P, Sandoval B, Bulos ML, Iaconelli J, Chatterjee AK, Wiseman RL, Schultz PG, Bollong MJ. Ko Y, et al. Among authors: ibrahim l. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120. doi: 10.1073/pnas.2300763120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155889 Free PMC article.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, Chatterjee AK, Shen W, Camargo FD, Schultz PG, Bollong MJ. Shalhout SZ, et al. Among authors: ibrahim l. Nat Chem Biol. 2021 Jul;17(7):767-775. doi: 10.1038/s41589-021-00755-0. Epub 2021 Mar 15. Nat Chem Biol. 2021. PMID: 33723431
Small-Molecule Stimulators of NRF1 Transcriptional Activity.
Iaconelli J, Ibrahim L, Chen E, Hull M, Schultz PG, Bollong MJ. Iaconelli J, et al. Among authors: ibrahim l. Chembiochem. 2020 Jul 1;21(13):1816-1819. doi: 10.1002/cbic.201900487. Epub 2019 Nov 8. Chembiochem. 2020. PMID: 31596542
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Jo J, Kim J, Ibrahim L, Kumar M, Iaconelli J, Tran CS, Moon HR, Jung Y, Wiseman RL, Lairson LL, Chatterjee AK, Bollong MJ, Yun H. Jo J, et al. Among authors: ibrahim l. Bioorg Med Chem Lett. 2023 Jun 1;89:129306. doi: 10.1016/j.bmcl.2023.129306. Epub 2023 Apr 26. Bioorg Med Chem Lett. 2023. PMID: 37116763
CRY2 missense mutations suppress P53 and enhance cell growth.
Chan AB, Parico GCG, Fribourgh JL, Ibrahim LH, Bollong MJ, Partch CL, Lamia KA. Chan AB, et al. Among authors: ibrahim lh. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2101416118. doi: 10.1073/pnas.2101416118. Proc Natl Acad Sci U S A. 2021. PMID: 34183418 Free PMC article.
227 results