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Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway.
Chronopoulos A, Thorpe SD, Cortes E, Lachowski D, Rice AJ, Mykuliak VV, Róg T, Lee DA, Hytönen VP, Del Río Hernández AE. Chronopoulos A, et al. Among authors: hytonen vp. Nat Mater. 2020 Jun;19(6):669-678. doi: 10.1038/s41563-019-0567-1. Epub 2020 Jan 6. Nat Mater. 2020. PMID: 31907416 Free PMC article.
PIP2 and Talin Join Forces to Activate Integrin.
Orłowski A, Kukkurainen S, Pöyry A, Rissanen S, Vattulainen I, Hytönen VP, Róg T. Orłowski A, et al. Among authors: hytonen vp. J Phys Chem B. 2015 Sep 24;119(38):12381-9. doi: 10.1021/acs.jpcb.5b06457. Epub 2015 Sep 9. J Phys Chem B. 2015. PMID: 26309152
Mechanotransduction in talin through the interaction of the R8 domain with DLC1.
Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice A, von Essen M, Hytönen VP, Del Río Hernández A. Haining AWM, et al. Among authors: hytonen vp. PLoS Biol. 2018 Jul 20;16(7):e2005599. doi: 10.1371/journal.pbio.2005599. eCollection 2018 Jul. PLoS Biol. 2018. PMID: 30028837 Free PMC article.
Cell Adhesion by Integrins.
Bachmann M, Kukkurainen S, Hytönen VP, Wehrle-Haller B. Bachmann M, et al. Among authors: hytonen vp. Physiol Rev. 2019 Oct 1;99(4):1655-1699. doi: 10.1152/physrev.00036.2018. Physiol Rev. 2019. PMID: 31313981 Free article. Review.
Induction of ligand promiscuity of αVβ3 integrin by mechanical force.
Bachmann M, Schäfer M, Mykuliak VV, Ripamonti M, Heiser L, Weißenbruch K, Krübel S, Franz CM, Hytönen VP, Wehrle-Haller B, Bastmeyer M. Bachmann M, et al. Among authors: hytonen vp. J Cell Sci. 2020 May 11;133(9):jcs242404. doi: 10.1242/jcs.242404. J Cell Sci. 2020. PMID: 32193334
The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering.
Kukkurainen S, Azizi L, Zhang P, Jacquier MC, Baikoghli M, von Essen M, Tuukkanen A, Laitaoja M, Liu X, Rahikainen R, Orłowski A, Jänis J, Määttä JAE, Varjosalo M, Vattulainen I, Róg T, Svergun D, Cheng RH, Wu J, Hytönen VP, Wehrle-Haller B. Kukkurainen S, et al. Among authors: hytonen vp. J Cell Sci. 2020 Oct 12;133(19):jcs239202. doi: 10.1242/jcs.239202. J Cell Sci. 2020. PMID: 33046605 Free PMC article.
189 results