Abstract
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers.
Keywords:
cell adhesion; fibronectin; integrin; mechanosensing; talin.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Cell Adhesion*
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Cell Membrane / metabolism*
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Cell Proliferation
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Extracellular Matrix / metabolism*
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Humans
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Integrins / chemistry
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Integrins / metabolism*
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Intracellular Signaling Peptides and Proteins / metabolism
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Mechanotransduction, Cellular*
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Models, Molecular
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Phosphoproteins / metabolism
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Protein Conformation
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Structure-Activity Relationship
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Trans-Activators
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Transcription Factors
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Integrins
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Intracellular Signaling Peptides and Proteins
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Phosphoproteins
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Trans-Activators
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Transcription Factors
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
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WWTR1 protein, human
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YAP-Signaling Proteins
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YAP1 protein, human