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Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production.
Molina-López C, Hurtado-Navarro L, García CJ, Angosto-Bazarra D, Vallejo F, Tapia-Abellán A, Marques-Soares JR, Vargas C, Bujan-Rivas S, Tomás-Barberán FA, Arostegui JI, Pelegrin P. Molina-López C, et al. Among authors: hurtado navarro l. Nat Commun. 2024 Feb 6;15(1):1096. doi: 10.1038/s41467-024-44990-0. Nat Commun. 2024. PMID: 38321014 Free PMC article.
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy.
Hurtado-Navarro L, Cuenca-Zamora EJ, Zamora L, Bellosillo B, Such E, Soler-Espejo E, Martínez-Banaclocha H, Hernández-Rivas JM, Marco-Ayala J, Martínez-Alarcón L, Linares-Latorre L, García-Ávila S, Amat-Martínez P, González T, Arnan M, Pomares-Marín H, Carreño-Tarragona G, Chen-Liang TH, Herranz MT, García-Palenciano C, Morales ML, Jerez A, Lozano ML, Teruel-Montoya R, Pelegrín P, Ferrer-Marín F. Hurtado-Navarro L, et al. Cell Rep Med. 2023 Dec 19;4(12):101329. doi: 10.1016/j.xcrm.2023.101329. Cell Rep Med. 2023. PMID: 38118408 Free PMC article.
Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure.
Malhotra S, Hurtado-Navarro L, Pappolla A, Villar LMM, Río J, Montalban X, Pelegrin P, Comabella M. Malhotra S, et al. Among authors: hurtado navarro l. Neurol Neuroimmunol Neuroinflamm. 2023 Mar 27;10(3):e200100. doi: 10.1212/NXI.0000000000200100. Print 2023 May. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 36973075 Free PMC article.
Early-onset recurrent panniculitis as a phenotype of NLRC4-associated autoinflammatory syndrome: Characterization of pathogenicity of the p.Ser445Pro NLRC4 variant.
Gil-Lianes J, Gariup G, Iranzo-Fernández P, Mensa-Vilaró A, Peñín-Franch A, Hurtado-Navarro L, Pelegrin P, Aróstegui JI. Gil-Lianes J, et al. Among authors: hurtado navarro l. Australas J Dermatol. 2023 May;64(2):260-267. doi: 10.1111/ajd.14005. Epub 2023 Feb 16. Australas J Dermatol. 2023. PMID: 36797819
Assessment of ASC Oligomerization by Flow Cytometry.
Hurtado-Navarro L, Baroja-Mazo A, Martínez-Banaclocha H, Pelegrín P. Hurtado-Navarro L, et al. Methods Mol Biol. 2022;2459:1-9. doi: 10.1007/978-1-0716-2144-8_1. Methods Mol Biol. 2022. PMID: 35212949
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