Huber AD - Search Results

1

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.

Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T. Bwayi MN, et al. Among authors: huber ad. Nucleic Acids Res. 2022 Apr 8;50(6):3254-3275. doi: 10.1093/nar/gkac133. Nucleic Acids Res. 2022. PMID: 35212371 Free PMC article.

2

Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment.

Huber AD, Chen T. Huber AD, et al. Cell Chem Biol. 2019 Mar 21;26(3):314-316. doi: 10.1016/j.chembiol.2019.03.004. Cell Chem Biol. 2019. PMID: 30901558 Free article.

3

CITCO Directly Binds to and Activates Human Pregnane X Receptor.

Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T. Lin W, et al. Among authors: huber ad. Mol Pharmacol. 2020 Mar;97(3):180-190. doi: 10.1124/mol.119.118513. Epub 2019 Dec 27. Mol Pharmacol. 2020. PMID: 31882411 Free PMC article.

4

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.

Wright WC, Chenge J, Wang J, Girvan HM, Yang L, Chai SC, Huber AD, Wu J, Oladimeji PO, Munro AW, Chen T. Wright WC, et al. Among authors: huber ad. J Med Chem. 2020 Feb 13;63(3):1415-1433. doi: 10.1021/acs.jmedchem.9b02067. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31965799 Free PMC article.

5

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.

Huber AD, Wright WC, Lin W, Majumder K, Low JA, Wu J, Buchman CD, Pintel DJ, Chen T. Huber AD, et al. Cell Mol Life Sci. 2021 Jan;78(1):317-335. doi: 10.1007/s00018-020-03505-y. Epub 2020 Mar 30. Cell Mol Life Sci. 2021. PMID: 32232515 Free PMC article.

6

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.

Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T. Wang J, et al. Among authors: huber ad. J Am Chem Soc. 2021 Nov 10;143(44):18467-18480. doi: 10.1021/jacs.1c07066. Epub 2021 Oct 14. J Am Chem Soc. 2021. PMID: 34648292 Free PMC article.

7

SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.

Huber AD, Li Y, Lin W, Galbraith AN, Mishra A, Porter SN, Wu J, Florke Gee RR, Zhuang W, Pruett-Miller SM, Peng J, Chen T. Huber AD, et al. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320. doi: 10.1021/acsmedchemlett.2c00223. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978691 Free PMC article.

8

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond.

Poudel S, Huber AD, Chen T. Poudel S, et al. Among authors: huber ad. Drug Metab Dispos. 2023 Feb;51(2):228-236. doi: 10.1124/dmd.122.000858. Epub 2022 Sep 18. Drug Metab Dispos. 2023. PMID: 36116789 Free PMC article. Review.

9

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.

Huber AD, Poudel S, Li Y, Lin W, Wu J, Miller DJ, Chen T. Huber AD, et al. Structure. 2023 Dec 7;31(12):1545-1555.e9. doi: 10.1016/j.str.2023.08.020. Epub 2023 Sep 19. Structure. 2023. PMID: 37729916

10

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation.

Florke Gee RR, Huber AD, Wu J, Bajpai R, Loughran AJ, Pruett-Miller SM, Chen T. Florke Gee RR, et al. Among authors: huber ad. Acta Pharm Sin B. 2023 Nov;13(11):4523-4534. doi: 10.1016/j.apsb.2023.07.014. Epub 2023 Jul 20. Acta Pharm Sin B. 2023. PMID: 37969738 Free PMC article.

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