Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment

Andrew D Huber; Taosheng Chen

doi:10.1016/j.chembiol.2019.03.004

Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment

Cell Chem Biol. 2019 Mar 21;26(3):314-316. doi: 10.1016/j.chembiol.2019.03.004.

Authors

Andrew D Huber¹, Taosheng Chen²

Affiliations

¹ Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
² Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: taosheng.chen@stjude.org.

PMID: 30901558
DOI: 10.1016/j.chembiol.2019.03.004

Abstract

In this issue of Cell Chemical Biology, Mo et al. (2019) report the development and validation of a co-culture system with cancer and immune cells that is suitable for high-throughput screening. The method is an important step forward in technologies for identifying cancer-cell-specific immunotherapies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Early Detection of Cancer
Humans
Immunologic Factors
Immunotherapy
Neoplasms*
Tumor Microenvironment*

Substances

Immunologic Factors

Grants and funding

R35 GM118041/GM/NIGMS NIH HHS/United States