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Nucleic acid-based drugs for patients with solid tumours.
Huayamares SG, Loughrey D, Kim H, Dahlman JE, Sorscher EJ. Huayamares SG, et al. Nat Rev Clin Oncol. 2024 Apr 8. doi: 10.1038/s41571-024-00883-1. Online ahead of print. Nat Rev Clin Oncol. 2024. PMID: 38589512 Review.
Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska K, Huayamares SG, Hua X, Han K, Loughrey D, Hatit MZC, Del Cid A, Ni H, Shajii A, Li A, Muralidharan A, Peck HE, Tiegreen KE, Jia S, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: huayamares sg. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307801120. doi: 10.1073/pnas.2307801120. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437539 Free PMC article.
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.
Hatit MZC, Dobrowolski CN, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Zenhausern R, Paunovska K, Peck HE, Kim J, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE. Hatit MZC, et al. Among authors: huayamares sg. Nat Chem. 2023 Apr;15(4):508-515. doi: 10.1038/s41557-023-01138-9. Epub 2023 Mar 2. Nat Chem. 2023. PMID: 36864143
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo.
Radmand A, Lokugamage MP, Kim H, Dobrowolski C, Zenhausern R, Loughrey D, Huayamares SG, Hatit MZC, Ni H, Del Cid A, Da Silva Sanchez AJ, Paunovska K, Schrader Echeverri E, Shajii A, Peck H, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: huayamares sg. Nano Lett. 2023 Feb 8;23(3):993-1002. doi: 10.1021/acs.nanolett.2c04479. Epub 2023 Jan 26. Nano Lett. 2023. PMID: 36701517 Free PMC article.
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.
Da Silva Sanchez AJ, Zhao K, Huayamares SG, Hatit MZC, Lokugamage MP, Loughrey D, Dobrowolski C, Wang S, Kim H, Paunovska K, Kuzminich Y, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: huayamares sg. J Control Release. 2023 Jan;353:270-277. doi: 10.1016/j.jconrel.2022.11.037. Epub 2022 Nov 30. J Control Release. 2023. PMID: 36423872 Free PMC article.
Brain Homogenate Decoys for Antigen-Specific Cell Amplification.
Griffin JD, Huayamares SG, Walston TR, Song JY, Shao M, Sedlacek AR, Diaz DL, Chakravarti AR, Berkland CJ. Griffin JD, et al. Among authors: huayamares sg. ACS Appl Bio Mater. 2021 Jan 18;4(1):387-391. doi: 10.1021/acsabm.0c01048. Epub 2020 Dec 23. ACS Appl Bio Mater. 2021. PMID: 35014289
Remote Sensing and Remote Actuation via Silicone-Magnetic Nanorod Composites.
Stottlemire BJ, Miller JD, Whitlow J, Huayamares SG, Dhar P, He M, Berkland CJ. Stottlemire BJ, et al. Among authors: huayamares sg. Adv Mater Technol. 2021 Jun;6(6):2001099. doi: 10.1002/admt.202001099. Epub 2021 Apr 22. Adv Mater Technol. 2021. PMID: 36304209 Free PMC article.
13 results