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BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir.
Tang W-F, Chang Y-H, Lin C-C, Jheng J-R, Hsieh C-F, Chin Y-F, Chang T-Y, Lee J-C, Liang P-H, Lin C-Y, Lin G-H, Cai J-Y, Chen Y-L, Chen Y-S, Tsai S-K, Liu P-C, Yang C-M, Shadbahr T, Tang J, Hsu Y-L, Huang C-H, Wang L-Y, Chen CC, Kau J-H, Hung Y-J, Lee H-Y, Wang W-C, Tsai H-P, Horng J-T. Tang W-F, et al. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0095623. doi: 10.1128/aac.00956-23. Epub 2024 Mar 6. Antimicrob Agents Chemother. 2024. PMID: 38446062 Free PMC article.
Two Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Bateman RJ, Smith J, Donohue MC, Delmar P, Abbas R, Salloway S, Wojtowicz J, Blennow K, Bittner T, Black SE, Klein G, Boada M, Grimmer T, Tamaoka A, Perry RJ, Turner RS, Watson D, Woodward M, Thanasopoulou A, Lane C, Baudler M, Fox NC, Cummings JL, Fontoura P, Doody RS; GRADUATE I and II Investigators and the Gantenerumab Study Group. Bateman RJ, et al. N Engl J Med. 2023 Nov 16;389(20):1862-1876. doi: 10.1056/NEJMoa2304430. N Engl J Med. 2023. PMID: 37966285 Clinical Trial.
Anti-viral and Anti-inflammatory Isoflavonoids from Ukrainian Iris aphylla Rhizomes: Structure-Activity Relationship Coupled with ChemGPS-NP Analysis.
Mykhailenko O, Hsieh CF, El-Shazly M, Nikishin A, Kovalyov V, Shynkarenko P, Ivanauskas L, Chen BH, Horng JT, Hwang TL, Georgiyants V, Korinek M. Mykhailenko O, et al. Among authors: hsieh cf. Planta Med. 2023 Sep;89(11):1063-1073. doi: 10.1055/a-2063-5265. Epub 2023 Mar 28. Planta Med. 2023. PMID: 36977489
139 results