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Synthesis of a Novel Type of 2,3'-BIMs via Platinum-Catalysed Reaction of Indolylallenes with Indoles.
Chemistry. 2018 Apr 20;24(23):6105-6114. doi: 10.1002/chem.201705417. Epub 2018 Mar 5.
Chemistry. 2018.
PMID: 29393548
Free PMC article.
Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines.
Hunt T, Atherton-Watson HC, Axford J, Collingwood SP, Coote KJ, Cox B, Czarnecki S, Danahay H, Devereux N, Howsham C, Hunt P, Paddock V, Paisley D, Young A.
Hunt T, et al. Among authors: howsham c.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):929-32. doi: 10.1016/j.bmcl.2011.12.016. Epub 2011 Dec 8.
Bioorg Med Chem Lett. 2012.
PMID: 22197144
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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Grand DL, Gosling M, Baettig U, Bahra P, Bala K, Brocklehurst C, Budd E, Butler R, Cheung AK, Choudhury H, Collingwood SP, Cox B, Danahay H, Edwards L, Everatt B, Glaenzel U, Glotin AL, Groot-Kormelink P, Hall E, Hatto J, Howsham C, Hughes G, King A, Koehler J, Kulkarni S, Lightfoot M, Nicholls I, Page C, Pergl-Wilson G, Popa MO, Robinson R, Rowlands D, Sharp T, Spendiff M, Stanley E, Steward O, Taylor RJ, Tranter P, Wagner T, Watson H, Williams G, Wright P, Young A, Sandham DA.
Grand DL, et al. Among authors: howsham c.
J Med Chem. 2021 Jun 10;64(11):7241-7260. doi: 10.1021/acs.jmedchem.1c00343. Epub 2021 May 24.
J Med Chem. 2021.
PMID: 34028270
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Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines.
Hunt T, Atherton-Watson HC, Collingwood SP, Coote KJ, Czarnecki S, Danahay H, Howsham C, Hunt P, Paisley D, Young A.
Hunt T, et al. Among authors: howsham c.
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2877-9. doi: 10.1016/j.bmcl.2012.02.067. Epub 2012 Mar 3.
Bioorg Med Chem Lett. 2012.
PMID: 22425452
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Biomimetic synthesis of resorcylate natural products utilizing late stage aromatization: concise total syntheses of the marine antifungal agents 15G256iota and 15G256beta.
Navarro I, Basset JF, Hebbe S, Major SM, Werner T, Howsham C, Bräckow J, Barrett AG.
Navarro I, et al. Among authors: howsham c.
J Am Chem Soc. 2008 Aug 6;130(31):10293-8. doi: 10.1021/ja803445u. Epub 2008 Jul 9.
J Am Chem Soc. 2008.
PMID: 18611011
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