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Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.
Balibar CJ, Klein DJ, Zamlynny B, Diamond TL, Fang Z, Cheney CA, Kristoff J, Lu M, Bukhtiyarova M, Ou Y, Xu M, Ba L, Carroll SS, El Marrouni A, Fay JF, Forster A, Goh SL, Gu M, Krosky D, Rosenbloom DIS, Sheth P, Wang D, Wu G, Zebisch M, Zhao T, Zuck P, Grobler J, Hazuda DJ, Howell BJ, Converso A. Balibar CJ, et al. Among authors: howell bj. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. doi: 10.1126/scitranslmed.abn2038. Epub 2023 Feb 22. Sci Transl Med. 2023. PMID: 36812345
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.
Wu G, Swanson M, Talla A, Graham D, Strizki J, Gorman D, Barnard RJ, Blair W, Søgaard OS, Tolstrup M, Østergaard L, Rasmussen TA, Sekaly RP, Archin NM, Margolis DM, Hazuda DJ, Howell BJ. Wu G, et al. Among authors: howell bj. JCI Insight. 2017 Aug 17;2(16):e92901. doi: 10.1172/jci.insight.92901. eCollection 2017 Aug 17. JCI Insight. 2017. PMID: 28814661 Free PMC article.
CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.
Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ. Abdel-Mohsen M, et al. Sci Transl Med. 2018 Apr 18;10(437):eaar6759. doi: 10.1126/scitranslmed.aar6759. Sci Transl Med. 2018. PMID: 29669853 Free PMC article.
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, Wolkenberg S, Beshore D, Duffy JL, Chung CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, Wu G, Howell BJ, Barnard RJO, Kozlowski J. Yu W, et al. Among authors: howell bj. Bioorg Med Chem Lett. 2020 Jul 1;30(13):127197. doi: 10.1016/j.bmcl.2020.127197. Epub 2020 Apr 15. Bioorg Med Chem Lett. 2020. PMID: 32331932
[No title available]
[No authors listed] [No authors listed] PMID: 32556126
81 results