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LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes.
Della Valle F, Reddy P, Yamamoto M, Liu P, Saera-Vila A, Bensaddek D, Zhang H, Prieto Martinez J, Abassi L, Celii M, Ocampo A, Nuñez Delicado E, Mangiavacchi A, Aiese Cigliano R, Rodriguez Esteban C, Horvath S, Izpisua Belmonte JC, Orlando V. Della Valle F, et al. Among authors: horvath s. Sci Transl Med. 2022 Aug 10;14(657):eabl6057. doi: 10.1126/scitranslmed.abl6057. Epub 2022 Aug 10. Sci Transl Med. 2022. PMID: 35947677
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.
Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Esteban CR, Reddy P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH. Jing Y, et al. Among authors: horvath s. Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. doi: 10.1016/j.stem.2023.09.007. Epub 2023 Oct 12. Cell Stem Cell. 2023. PMID: 37832549
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice.
Hernandez-Benitez R, Wang C, Shi L, Ouchi Y, Zhong C, Hishida T, Liao HK, Magill EA, Memczak S, Soligalla RD, Fresia C, Hatanaka F, Lamas V, Guillen I, Sahu S, Yamamoto M, Shao Y, Aguirre-Vazquez A, Nuñez Delicado E, Guillen P, Rodriguez Esteban C, Qu J, Reddy P, Horvath S, Liu GH, Magistretti P, Izpisua Belmonte JC. Hernandez-Benitez R, et al. Among authors: horvath s. Cell Rep Med. 2024 Mar 19;5(3):101449. doi: 10.1016/j.xcrm.2024.101449. Cell Rep Med. 2024. PMID: 38508141 Free PMC article.
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle.
Jones RG 3rd, Dimet-Wiley A, Haghani A, da Silva FM, Brightwell CR, Lim S, Khadgi S, Wen Y, Dungan CM, Brooke RT, Greene NP, Peterson CA, McCarthy JJ, Horvath S, Watowich SJ, Fry CS, Murach KA. Jones RG 3rd, et al. Among authors: horvath s. J Physiol. 2023 Feb;601(4):763-782. doi: 10.1113/JP283836. Epub 2023 Jan 24. J Physiol. 2023. PMID: 36533424 Free PMC article.
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients.
Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. Mertens J, et al. Among authors: horvath s. Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27. Cell Stem Cell. 2021. PMID: 33910058 Free PMC article.
Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging.
Bobba-Alves N, Sturm G, Lin J, Ware SA, Karan KR, Monzel AS, Bris C, Procaccio V, Lenaers G, Higgins-Chen A, Levine M, Horvath S, Santhanam BS, Kaufman BA, Hirano M, Epel E, Picard M. Bobba-Alves N, et al. Among authors: horvath s. Psychoneuroendocrinology. 2023 Sep;155:106322. doi: 10.1016/j.psyneuen.2023.106322. Epub 2023 Jun 14. Psychoneuroendocrinology. 2023. PMID: 37423094 Free PMC article.
Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.
Bareja A, Lee DE, Ho T, Waitt G, McKay LH, Hannou SA, Orenduff MC, McGreevy KM, Binder A, Ryan CP, Soderblom EJ, Belsky DW, Ferrucci L, Das JK, Banskota N, Kraus VB, Huebner JL, Kraus WE, Huffman KM, Baht GS, Horvath S, Parmer RJ, Miles LA, White JP. Bareja A, et al. Among authors: horvath s. Cell Rep. 2024 Mar 26;43(3):113881. doi: 10.1016/j.celrep.2024.113881. Epub 2024 Mar 4. Cell Rep. 2024. PMID: 38442019 Free PMC article.
Epigenetic aging of human blood cells is influenced by the age of the host body.
Holland P, Istre M, Ali MM, Gedde-Dahl T, Buechner J, Wildhagen M, Brunvoll SH, Horvath S, Matsuyama S, Dahl JA, Stölzel F, Søraas A. Holland P, et al. Among authors: horvath s. Aging Cell. 2024 Mar 4:e14112. doi: 10.1111/acel.14112. Online ahead of print. Aging Cell. 2024. PMID: 38439206 Free article.
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans.
Benavente ED, Hartman RJG, Sakkers TR, Wesseling M, Sloots Y, Slenders L, Boltjes A, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, de Winther MPJ, Kuiper J, Civelek M, van der Laan SW, Horvath S, Onland-Moret C, Mokry M, Pasterkamp G, den Ruijter HM. Benavente ED, et al. Among authors: horvath s. Arterioscler Thromb Vasc Biol. 2024 Apr 18. doi: 10.1161/ATVBAHA.123.320692. Online ahead of print. Arterioscler Thromb Vasc Biol. 2024. PMID: 38634280 Free article.
1,277 results