Epigenetic aging of human blood cells is influenced by the age of the host body

Petter Holland; Mette Istre; Maryan M Ali; Tobias Gedde-Dahl; Jochen Buechner; Mari Wildhagen; Sonja H Brunvoll; Steve Horvath; Shigemi Matsuyama; John Arne Dahl; Friedrich Stölzel; Arne Søraas

doi:10.1111/acel.14112

Epigenetic aging of human blood cells is influenced by the age of the host body

Aging Cell. 2024 Mar 4:e14112. doi: 10.1111/acel.14112. Online ahead of print.

Authors

Affiliations

¹ Department of Microbiology, Oslo University Hospital, Oslo, Norway.
² Department of Internal medisin, Baerum Hospital, Drammen, Norway.
³ Department of Hematology, Oslo University Hospital, Oslo, Norway.
⁴ Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
⁵ Altos Labs, Cambridge, UK.
⁶ Department of Medicine, Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, Ohio, USA.
⁷ Division of Stem Cell Transplantation and Cellular Therapies, Department of Internal Medicine II, University Hospital Schleswig-Holstein Kiel, Kiel University, Kiel, Germany.
⁸ Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.

PMID: 38439206
DOI: 10.1111/acel.14112

Abstract

Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo.

Keywords: aging; epigenetic; hematopoietic; hsc; human; parabiosis; transplantation.

Abstract

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