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Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics.
House RV, Broge TA, Suscovich TJ, Snow DM, Tomic MT, Nonet G, Bajwa K, Zhu G, Martinez Z, Hackett K, Earnhart CG, Dorsey NM, Hopkins SA, Natour DS, Davis HD, Anderson MS, Gainey MR, Cobb RR. House RV, et al. Among authors: hopkins sa. PLoS One. 2022 Jun 3;17(6):e0267796. doi: 10.1371/journal.pone.0267796. eCollection 2022. PLoS One. 2022. PMID: 35657812 Free PMC article.
A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques.
Cobb RR, Nkolola J, Gilchuk P, Chandrashekar A, Yu J, House RV, Earnhart CG, Dorsey NM, Hopkins SA, Snow DM, Chen RE, VanBlargan LA, Hechenblaickner M, Hoppe B, Collins L, Tomic MT, Nonet GH, Hackett K, Slaughter JC, Lewis MG, Andersen H, Cook A, Diamond MS, Carnahan RH, Barouch DH, Crowe JE Jr. Cobb RR, et al. Among authors: hopkins sa. Med. 2022 Mar 11;3(3):188-203.e4. doi: 10.1016/j.medj.2022.01.004. Epub 2022 Feb 3. Med. 2022. PMID: 35132398 Free PMC article.
Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW, Lillo AM, Sundaram S, Bloom J, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. bioRxiv [Preprint]. 2023 Apr 24:2022.10.21.513237. doi: 10.1101/2022.10.21.513237. bioRxiv. 2023. PMID: 36324800 Free PMC article. Preprint.
Computationally restoring the potency of a clinical antibody against Omicron.
Desautels TA, Arrildt KT, Zemla AT, Lau EY, Zhu F, Ricci D, Cronin S, Zost SJ, Binshtein E, Scheaffer SM, Dadonaite B, Petersen BK, Engdahl TB, Chen E, Handal LS, Hall L, Goforth JW, Vashchenko D, Nguyen S, Weilhammer DR, Lo JK, Rubinfeld B, Saada EA, Weisenberger T, Lee TH, Whitener B, Case JB, Ladd A, Silva MS, Haluska RM, Grzesiak EA, Earnhart CG, Hopkins S, Bates TW, Thackray LB, Segelke BW; Tri-lab COVID-19 Consortium; Lillo AM, Sundaram S, Bloom JD, Diamond MS, Crowe JE Jr, Carnahan RH, Faissol DM. Desautels TA, et al. Nature. 2024 May 8. doi: 10.1038/s41586-024-07385-1. Online ahead of print. Nature. 2024. PMID: 38720086
55 results