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Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WG. Verlinde CL, et al. Among authors: hol wg. Curr Top Med Chem. 2009;9(18):1678-87. doi: 10.2174/156802609790102383. Curr Top Med Chem. 2009. PMID: 19929835 Free PMC article. Review.
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Bosch J, et al. Among authors: hol wg. J Med Chem. 2006 Oct 5;49(20):5939-46. doi: 10.1021/jm060429m. J Med Chem. 2006. PMID: 17004709
Structural genomics of pathogenic protozoa: an overview.
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG. Fan E, et al. Among authors: hol wg. Methods Mol Biol. 2008;426:497-513. doi: 10.1007/978-1-60327-058-8_33. Methods Mol Biol. 2008. PMID: 18542886 Review.
Screening a fragment cocktail library using ultrafiltration.
Shibata S, Zhang Z, Korotkov KV, Delarosa J, Napuli A, Kelley AM, Mueller N, Ross J, Zucker FH, Buckner FS, Merritt EA, Verlinde CL, Van Voorhis WC, Hol WG, Fan E. Shibata S, et al. Among authors: hol wg. Anal Bioanal Chem. 2011 Sep;401(5):1585-91. doi: 10.1007/s00216-011-5225-7. Epub 2011 Jul 13. Anal Bioanal Chem. 2011. PMID: 21750879 Free PMC article.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Koh CY, Siddaramaiah LK, Ranade RM, Nguyen J, Jian T, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Koh CY, et al. Among authors: hol wg. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1684-98. doi: 10.1107/S1399004715007683. Epub 2015 Jul 31. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26249349 Free PMC article.
Prediction of protein crystallization outcome using a hybrid method.
Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG. Zucker FH, et al. Among authors: hol wg. J Struct Biol. 2010 Jul;171(1):64-73. doi: 10.1016/j.jsb.2010.03.016. Epub 2010 Mar 27. J Struct Biol. 2010. PMID: 20347992 Free PMC article.
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Robien MA, et al. Among authors: hol wg. Proteins. 2006 Mar 15;62(3):570-7. doi: 10.1002/prot.20801. Proteins. 2006. PMID: 16345073
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Arakaki T, Le Trong I, Phizicky E, Quartley E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Worthey E, Myler PJ, Kim D, Baker D, Hol WG, Merritt EA. Arakaki T, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):175-9. doi: 10.1107/S1744309106005902. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511295 Free PMC article.
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Hol WG, Merritt EA. Holmes MA, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):180-5. doi: 10.1107/S1744309106005847. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511296 Free PMC article.
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Arakaki T, Neely H, Boni E, Mueller N, Buckner FS, Van Voorhis WC, Lauricella A, DeTitta G, Luft J, Hol WG, Merritt EA. Arakaki T, et al. Among authors: hol wg. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):178-82. doi: 10.1107/S1744309107007580. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329808 Free PMC article.
346 results