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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Shimazu T, et al. Among authors: hirschey md. Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6. Science. 2013. PMID: 23223453 Free PMC article.
The sirtuins, oxidative stress and aging: an emerging link.
Merksamer PI, Liu Y, He W, Hirschey MD, Chen D, Verdin E. Merksamer PI, et al. Among authors: hirschey md. Aging (Albany NY). 2013 Mar;5(3):144-50. doi: 10.18632/aging.100544. Aging (Albany NY). 2013. PMID: 23474711 Free PMC article. Review.
Acetylation of mitochondrial proteins.
Hirschey MD, Shimazu T, Huang JY, Verdin E. Hirschey MD, et al. Methods Enzymol. 2009;457:137-47. doi: 10.1016/S0076-6879(09)05008-3. Methods Enzymol. 2009. PMID: 19426866
Mitochondrial sirtuins.
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Huang JY, et al. Among authors: hirschey md. Biochim Biophys Acta. 2010 Aug;1804(8):1645-51. doi: 10.1016/j.bbapap.2009.12.021. Epub 2010 Jan 7. Biochim Biophys Acta. 2010. PMID: 20060508 Review.
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. Hirschey MD, et al. Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778. Nature. 2010. PMID: 20203611 Free PMC article.
Acetate metabolism and aging: An emerging connection.
Shimazu T, Hirschey MD, Huang JY, Ho LT, Verdin E. Shimazu T, et al. Among authors: hirschey md. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):511-6. doi: 10.1016/j.mad.2010.05.001. Epub 2010 May 15. Mech Ageing Dev. 2010. PMID: 20478325
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, Verdin E. Hirschey MD, et al. Mol Cell. 2011 Oct 21;44(2):177-90. doi: 10.1016/j.molcel.2011.07.019. Mol Cell. 2011. PMID: 21856199 Free PMC article.
89 results