Acetate metabolism and aging: An emerging connection

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):511-6. doi: 10.1016/j.mad.2010.05.001. Epub 2010 May 15.

Abstract

Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetate-CoA Ligase / metabolism
  • Acetates / metabolism*
  • Acetyl Coenzyme A / metabolism
  • Acetylation
  • Age Factors
  • Aging / metabolism*
  • Animals
  • Cellular Senescence
  • Energy Metabolism
  • Humans
  • Longevity
  • Mitochondria / enzymology*
  • Sirtuins / metabolism*

Substances

  • Acetates
  • Acetyl Coenzyme A
  • Sirtuins
  • Acetate-CoA Ligase