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An mTORC1/2 dual inhibitor, AZD2014, acts as a lysosomal function activator and enhances gemtuzumab ozogamicin-induced apoptosis in primary human leukemia cells.
Mizutani Y, Inase A, Maimaitili Y, Miyata Y, Kitao A, Matsumoto H, Kawaguchi K, Higashime A, Goto H, Kurata K, Yakushijin K, Minami H, Matsuoka H. Mizutani Y, et al. Among authors: higashime a. Int J Hematol. 2019 Oct;110(4):490-499. doi: 10.1007/s12185-019-02701-2. Epub 2019 Jul 8. Int J Hematol. 2019. PMID: 31286402
A Pathogenic NRAS c.38G>A (p.G13D) Mutation in RARA Translocation-negative Acute Promyelocytic-like Leukemia with Concomitant Myelodysplastic Syndrome.
Goto H, Yakushijin K, Adachi Y, Matsumoto H, Yamamoto K, Matsumoto S, Yamashita T, Higashime A, Kawaguchi K, Kurata K, Matsuoka H, Minami H. Goto H, et al. Among authors: higashime a. Intern Med. 2023 May 1;62(9):1329-1334. doi: 10.2169/internalmedicine.0174-22. Epub 2022 Sep 21. Intern Med. 2023. PMID: 36130886 Free PMC article.
Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study.
Mizutani Y, Kawamoto S, Takahashi M, Doi H, Wakida K, Tabuchi S, Tanda M, Soga A, Chijiki R, Takakura H, Kawaguchi K, Higashime A, Watanabe M, Ichikawa H, Matsumoto S, Sakai R, Goto H, Kurata K, Kakiuchi S, Miyata Y, Uryu K, Inui Y, Kitao A, Yakushijin K, Matsuoka H, Minami H. Mizutani Y, et al. Among authors: higashime a. Intern Med. 2023 Oct 15;62(20):2949-2958. doi: 10.2169/internalmedicine.1314-22. Epub 2023 Feb 15. Intern Med. 2023. PMID: 36792187 Free PMC article. Clinical Trial.
GSK3 inhibitor enhances gemtuzumab ozogamicin-induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance.
Inase A, Maimaitili Y, Kimbara S, Mizutani Y, Miyata Y, Ohata S, Matsumoto H, Kitao A, Sakai R, Kawaguchi K, Higashime A, Nagao S, Kurata K, Goto H, Kawamoto S, Yakushijin K, Minami H, Matsuoka H. Inase A, et al. Among authors: higashime a. EJHaem. 2022 Dec 12;4(1):153-164. doi: 10.1002/jha2.600. eCollection 2023 Feb. EJHaem. 2022. PMID: 36819180 Free PMC article.
Safety and Accuracy of Professional Continuous Glucose Monitoring in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
Nagao S, Yakushijin K, Higashime A, Kawaguchi K, Watanabe M, Sakai R, Ichikawa H, Mizutani Y, Goto H, Kakiuchi S, Kurata K, Kitao A, Miyata Y, Imamura Y, Hirota Y, Takahashi M, Kawamoto S, Yamamoto K, Matsuoka H, Minami H. Nagao S, et al. Among authors: higashime a. Blood Cell Ther. 2023 Mar 24;6(2):54-60. doi: 10.31547/bct-2022-024. eCollection 2023 May 25. Blood Cell Ther. 2023. PMID: 37342353 Free PMC article.