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IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Laakso SM, Kekäläinen E, Rossi LH, Laurinolli TT, Mannerström H, Heikkilä N, Lehtoviita A, Perheentupa J, Jarva H, Arstila TP. Laakso SM, et al. Among authors: heikkila n. J Immunol. 2011 Aug 15;187(4):2023-30. doi: 10.4049/jimmunol.1100212. Epub 2011 Jul 13. J Immunol. 2011. PMID: 21753149 Clinical Trial.
Dysregulation of adaptive immune responses in complement C3-deficient patients.
Pekkarinen PT, Heikkilä N, Kisand K, Peterson P, Botto M, Daha MR, Drouet C, Isaac L, Helminen M, Haahtela T, Meri S, Jarva H, Arstila TP. Pekkarinen PT, et al. Among authors: heikkila n. Eur J Immunol. 2015 Mar;45(3):915-21. doi: 10.1002/eji.201444948. Epub 2015 Jan 19. Eur J Immunol. 2015. PMID: 25446578 Free article. Clinical Trial.
T cell receptor diversity in the human thymus.
Vanhanen R, Heikkilä N, Aggarwal K, Hamm D, Tarkkila H, Pätilä T, Jokiranta TS, Saramäki J, Arstila TP. Vanhanen R, et al. Among authors: heikkila n. Mol Immunol. 2016 Aug;76:116-22. doi: 10.1016/j.molimm.2016.07.002. Epub 2016 Jul 19. Mol Immunol. 2016. PMID: 27442982
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells.
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Hetemäki I, et al. Among authors: heikkila n. Sci Immunol. 2021 Nov 26;6(65):eabe3454. doi: 10.1126/sciimmunol.abe3454. Epub 2021 Nov 26. Sci Immunol. 2021. PMID: 34826260
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