Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Nelli Heikkilä; Reetta Vanhanen; Dawit A Yohannes; Päivi Saavalainen; Seppo Meri; T Sakari Jokiranta; Hanna Jarva; Ilkka P Mattila; David Hamm; Silja Sormunen; Jari Saramäki; T Petteri Arstila

doi:10.1002/eji.201948404

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Eur J Immunol. 2020 May;50(5):748-751. doi: 10.1002/eji.201948404. Epub 2020 Jan 14.

Authors

Nelli Heikkilä^{1

2}, Reetta Vanhanen^{1

2}, Dawit A Yohannes^{1

3}, Päivi Saavalainen^{1

3}, Seppo Meri^{1

2}, T Sakari Jokiranta², Hanna Jarva², Ilkka P Mattila⁴, David Hamm⁵, Silja Sormunen⁶, Jari Saramäki⁶, T Petteri Arstila^{1

2}

Affiliations

¹ Research Programs Unit, Translational Immunology, University of Helsinki, Helsinki, Finland.
² Medicum, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
³ Medicum, Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
⁴ Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.
⁵ Adaptive Biotechnologies, Seattle, Washington.
⁶ Department of Computer Science, Aalto University, Finland.

PMID: 31872865
DOI: 10.1002/eji.201948404

Abstract

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.

Keywords: CDR3; TCR repertoire; genetics; thymic selection; twins.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Complementarity Determining Regions / genetics*
Gene Expression
High-Throughput Nucleotide Sequencing
Humans
Receptors, Antigen, T-Cell, alpha-beta / classification
Receptors, Antigen, T-Cell, alpha-beta / genetics*
Receptors, Antigen, T-Cell, alpha-beta / immunology
T-Lymphocyte Subsets / classification
T-Lymphocyte Subsets / cytology
T-Lymphocyte Subsets / immunology
Thymus Gland / cytology
Thymus Gland / immunology
Twins, Monozygotic*
V(D)J Recombination / immunology*

Substances

Complementarity Determining Regions
Receptors, Antigen, T-Cell, alpha-beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding