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Page 1
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.
Wilk CM, Cathomas F, Török O, Le Berichel J, Park MD, Bigenwald C, Heaton GR, Hamon P, Troncoso L, Scull BP, Dangoor D, Silvin A, Fleischmann R, Belabed M, Lin H, Merad Taouli E, Boettcher S, Li L, Aubry A, Manz MG, Kofler JK, Yue Z, Lira SA, Ginhoux F, Crary JF, McClain KL, Picarsic JL, Russo SJ, Allen CE, Merad M. Wilk CM, et al. Among authors: heaton gr. Immunity. 2023 Dec 12;56(12):2790-2802.e6. doi: 10.1016/j.immuni.2023.11.011. Immunity. 2023. PMID: 38091952
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration.
Wilk CM, Cathomas F, Török O, Le Berichel J, Park MD, Heaton GR, Hamon P, Troncoso L, Scull BP, Dangoor D, Silvin A, Fleischmann R, Belabed M, Lin H, Taouli EM, Boettcher S, Manz MG, Kofler JK, Yue Z, Lira SA, Ginhoux F, Crary JF, McClain KL, Picarsic JL, Russo SJ, Allen CE, Merad M. Wilk CM, et al. Among authors: heaton gr. bioRxiv [Preprint]. 2023 Oct 11:2023.10.10.561744. doi: 10.1101/2023.10.10.561744. bioRxiv. 2023. PMID: 37873371 Free PMC article. Updated. Preprint.
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Harvey K, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mamais A, et al. Among authors: heaton gr. PLoS Biol. 2022 May 4;20(5):e3001621. doi: 10.1371/journal.pbio.3001621. eCollection 2022 May. PLoS Biol. 2022. PMID: 35507910 Free PMC article.
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mamais A, et al. Among authors: heaton gr. PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec. PLoS Biol. 2021. PMID: 34914695 Free PMC article.
Progress in LRRK2-Associated Parkinson's Disease Animal Models.
Seegobin SP, Heaton GR, Liang D, Choi I, Blanca Ramirez M, Tang B, Yue Z. Seegobin SP, et al. Among authors: heaton gr. Front Neurosci. 2020 Jul 15;14:674. doi: 10.3389/fnins.2020.00674. eCollection 2020. Front Neurosci. 2020. PMID: 32765209 Free PMC article. Review.
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Heaton GR, Landeck N, Mamais A, Nalls MA, Nixon-Abell J, Kumaran R, Beilina A, Pellegrini L, Li Y; International Parkinson Disease Genomics Consortium (IPDGC); Harvey K, Cookson MR. Heaton GR, et al. Neurobiol Dis. 2020 Jul;141:104948. doi: 10.1016/j.nbd.2020.104948. Epub 2020 May 17. Neurobiol Dis. 2020. PMID: 32434048 Free PMC article.
Ocular biomarkers of Alzheimer's disease.
Heaton GR, Davis BM, Turner LA, Cordeiro MF. Heaton GR, et al. Cent Nerv Syst Agents Med Chem. 2015;15(2):117-25. doi: 10.2174/1871524915666150319123015. Cent Nerv Syst Agents Med Chem. 2015. PMID: 25788142 Review.