Progress in LRRK2-Associated Parkinson's Disease Animal Models

Steven P Seegobin; George R Heaton; Dongxiao Liang; Insup Choi; Marian Blanca Ramirez; Beisha Tang; Zhenyu Yue

doi:10.3389/fnins.2020.00674

Progress in LRRK2-Associated Parkinson's Disease Animal Models

Front Neurosci. 2020 Jul 15:14:674. doi: 10.3389/fnins.2020.00674. eCollection 2020.

Authors

Steven P Seegobin^{1

2

3}, George R Heaton^{1

2

3}, Dongxiao Liang^{1

2

3

4}, Insup Choi^{1

2

3}, Marian Blanca Ramirez^{1

2

3}, Beisha Tang^{4

5}, Zhenyu Yue^{1

2

3}

Affiliations

¹ Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
² Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
³ Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
⁴ Department of Neurology, Xiangya Hospital, Central South University, Hunan, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China.

Abstract

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson's disease (PD). Several genetic manipulations of the LRRK2 gene have been developed in animal models such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish. These models can help us further understand the biological function and derive potential pathological mechanisms for LRRK2. Here we discuss common phenotypic themes found in LRRK2-associated PD animal models, highlight several issues that should be addressed in future models, and discuss emerging areas to guide their future development.

Keywords: C. elegans; Drosophila; LRRK2; models; phenotypes; rodent; zebrafish.

Publication types

Review

Abstract

Publication types

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