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Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution.
Ernst C, Andreassen PR, Giger GH, Nguyen BD, Gäbelein CG, Guillaume-Gentil O, Fattinger SA, Sellin ME, Hardt WD, Vorholt JA. Ernst C, et al. Among authors: hardt wd. PLoS Biol. 2024 Apr 29;22(4):e3002597. doi: 10.1371/journal.pbio.3002597. eCollection 2024 Apr. PLoS Biol. 2024. PMID: 38684033 Free PMC article.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Fattinger SA, Maurer L, Geiser P, Bernard EM, Enz U, Ganguillet S, Gül E, Kroon S, Demarco B, Mack V, Furter M, Barthel M, Pelczar P, Shao F, Broz P, Sellin ME, Hardt WD. Fattinger SA, et al. Among authors: hardt wd. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120. doi: 10.1073/pnas.2315503120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988464 Free PMC article.
From microbiome composition to functional engineering, one step at a time.
Burz SD, Causevic S, Dal Co A, Dmitrijeva M, Engel P, Garrido-Sanz D, Greub G, Hapfelmeier S, Hardt W-D, Hatzimanikatis V, Heiman CM, Herzog MK-M, Hockenberry A, Keel C, Keppler A, Lee S-J, Luneau J, Malfertheiner L, Mitri S, Ngyuen B, Oftadeh O, Pacheco AR, Peaudecerf F, Resch G, Ruscheweyh H-J, Sahin A, Sanders IR, Slack E, Sunagawa S, Tackmann J, Tecon R, Ugolini GS, Vacheron J, van der Meer JR, Vayena E, Vonaesch P, Vorholt JA. Burz SD, et al. Among authors: hardt w d. Microbiol Mol Biol Rev. 2023 Dec 20;87(4):e0006323. doi: 10.1128/mmbr.00063-23. Epub 2023 Nov 10. Microbiol Mol Biol Rev. 2023. PMID: 37947420 Free article. Review.
The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence.
Gül E, Bakkeren E, Salazar G, Steiger Y, Abi Younes A, Clerc M, Christen P, Fattinger SA, Nguyen BD, Kiefer P, Slack E, Ackermann M, Vorholt JA, Sunagawa S, Diard M, Hardt WD. Gül E, et al. Among authors: hardt wd. PLoS Biol. 2023 Aug 31;21(8):e3002253. doi: 10.1371/journal.pbio.3002253. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37651408 Free PMC article.
253 results